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Outcome depending on fusion status in the context with known clinical risk factors was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No prognostic significance was shown for SYT\u2010SSX fusion status and for histological grade. Highest significance of negative prognostic impact was found for large tumor size in uni\u2010 and multivariate analysis (<jats:italic>P<\/jats:italic>&lt; 0.01). Furthermore, male gender was shown to be an adverse prognostic factor in multivariate analysis (<jats:italic>P<\/jats:italic>= 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on our results, neither histological grading nor SYT\u2010SSX fusion status seems to be suitable for outcome prediction and risk stratification in localized SS treated according to the CWS. This is in contrast to several other publications concerning more heterogeneous age groups including children and adults, and this indicates that prognostic factors should not be interpreted apart from the particular study population and the therapeutic context.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26206","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T07:13:10Z","timestamp":1473750790000},"page":"89-95","source":"Crossref","is-referenced-by-count":38,"title":["The prognostic impact of SYT\u2010SSX fusion type and histological grade in pediatric patients with synovial sarcoma treated according to the CWS (Cooperative Weichteilsarkom Studie) trials"],"prefix":"10.1002","volume":"64","author":[{"given":"Sabine","family":"Stegmaier","sequence":"first","affiliation":[{"name":"Klinikum Stuttgart Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology) Stuttgart 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