{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:36:51Z","timestamp":1775176611702,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This retrospective study was undertaken to analyze the effectiveness and safety of surgery combined with postoperative <jats:sup>125<\/jats:sup>I seed brachytherapy in the treatment of mucoepidermoid carcinoma (MEC) of the parotid gland with risk factors in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>From September 2002 to January 2012, 24 patients, ages 5\u201316 years (mean, 13.2 years; median, 12.3 years), with MEC of the parotid gland were included. Patients with high risk factors received <jats:sup>125<\/jats:sup>I seed brachytherapy (median actuarial D90, 97 Gy) within 4 weeks following surgery. Radioactivity was 18.5\u201333.3 MBq per seed and the prescription dose was 60\u2013120 Gy. Overall and disease\u2010free survival rates, local control rate, and distant metastasis were recorded. Radiation\u2010associated late side effects, including dermatitis, hearing loss, thyroid nodules, and secondary malignancy, were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up period of 5\u201313.4 years (median, 7.2 years), the overall and disease\u2010free survival rates were all 100%. No patients developed local recurrence, regional\/distant metastasis, and no severe radiation\u2010associated complications including the second malignancy were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery combined with postoperative <jats:sup>125<\/jats:sup>I seed brachytherapy is effective and safe in the treatment of MEC of the parotid gland in pediatric patients, with no evidence of severe late radiation\u2010related complications. More patients and longer follow\u2010up data are still needed to prove the efficacy of <jats:sup>125<\/jats:sup>I brachytherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26217","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T16:05:09Z","timestamp":1472659509000},"page":"57-63","source":"Crossref","is-referenced-by-count":24,"title":["Surgery combined with postoperative <sup>125<\/sup>I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients"],"prefix":"10.1002","volume":"64","author":[{"given":"Ming\u2010hui","family":"Mao","sequence":"first","affiliation":[{"name":"Capital Medical University School of Stomatology  Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Capital Medical University School of Stomatology  Beijing P.R. 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