{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:03:48Z","timestamp":1753869828608,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granulomatous lung disease is a rare and perplexing differential in pediatrics. Pulmonary <jats:italic>Cryptococcus<\/jats:italic> falls into the differential but is not high on the list, particularly in a non\u2010AIDS patient. Methotrexate (MTX) is a commonly used agent for chemotherapy in oncology and has been documented to cause lung injury in both patients with rheumatologic and oncologic diseases. Our patient had chronic cough and then developed an opportunistic infection resulting in respiratory failure. Lung biopsy showed two underlying unusual diagnoses: MTX lung injury and cryptococcal pneumonia. His case is presented with particular attention to his prolonged road to diagnosis.<\/jats:p>","DOI":"10.1002\/pbc.26247","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T06:23:09Z","timestamp":1473661389000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiple unusual lung etiologies in a child with acute lymphocytic leukemia"],"prefix":"10.1002","volume":"64","author":[{"given":"Allison","family":"Bechtel","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Florida College of Medicine  Jacksonville Florida"},{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics Nemours Jacksonville  Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Joyce","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics Nemours Jacksonville  Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Dudek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Florida College of Medicine  Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Sarandria","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Florida College of Medicine  Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Pediatric Radiology Department of Pediatrics Nemours Jacksonville  Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali G.","family":"Saad","sequence":"additional","affiliation":[{"name":"Baptist Health\/MD Anderson Cancer Center and Wolfson Children's Hospital  Jacksonville Florida"},{"name":"Department of Pathology University of Mississippi  Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12410"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.749422"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2012.07.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(62)80355-2"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"59","article-title":"Pneumocystis jiroveci pneumonia","volume":"52","author":"Luks AM","year":"2007","journal-title":"Respir Care"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.093690"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.089276"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneumo.2013.08.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.515"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318236c502"},{"key":"e_1_2_6_13_1","first-page":"1103","article-title":"Cryptococcal meningitis during front\u2010line chemotherapy for acute lymphoblastic leukemia","volume":"85","author":"Urbini B","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000687"},{"issue":"10","key":"e_1_2_6_15_1","first-page":"1100","article-title":"Methotrexate\u2010induced interstitial pneumonitis in a child with acute lymphoblastic leukemia","volume":"45","author":"Tatsumoto C","year":"2004","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.576905"},{"issue":"11","key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.arbr.2015.05.012","article-title":"Protective effects of infliximab of lung injury induced by methotrexate","volume":"51","author":"Kurt A","year":"2015","journal-title":"Arch Bronchoneumol"}],"container-title":["Pediatric Blood &amp; 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