{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:55:26Z","timestamp":1754398526855,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sacrococcygeal teratoma (SCT) is the most common germ cell tumor (GCT) of infancy. Up to 35% of infants may have malignant elements. The standard of care for SCT with malignant elements (SCT\u2010ME) has been surgery and chemotherapy. However, cases where low\u2010stage SCT\u2010ME have been successfully observed following resection have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>To better understand the outcomes of low\u2010stage SCT\u2010ME that do not receive chemotherapy, we reviewed SCT pathology reports from five children's hospitals from 1999 to 2009. Information regarding staging workup, tumor markers, treatment, and outcome was collected for patients with stage I or II SCT\u2010ME. An English language literature review was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010four SCT were identified: 51 stage I and 23 stage II; 13 (18%) were SCT\u2010ME: 5 stage I and 8 stage II; four stage I and four stage II tumors were not treated with chemotherapy. No stage I tumors recurred; all of the stage II tumors recurred and were successfully salvaged, two had no ME at recurrence. We identified another 10 stage I SCT\u2010ME in the literature managed with active surveillance\u2014two recurred and were successfully treated with surgery and chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, of the 14 cases of stage I SCT\u2010ME, 12 survived with no recurrence and the two who did recur were successfully treated with platinum\u2010based chemotherapy (EFS = 86%, overall survival [OS] = 100%); this suggests that patients with stage I SCT\u2010ME could be observed after surgery and treated only upon recurrence. Stage II SCT\u2010ME require further study in a clinical trial setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26311","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T09:53:03Z","timestamp":1477561983000},"source":"Crossref","is-referenced-by-count":10,"title":["Is surgical resection and observation sufficient for stage I and II sacrococcygeal germ cell tumors? A case series and review"],"prefix":"10.1002","volume":"64","author":[{"given":"Rachel A.","family":"Egler","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics Rainbow Babies and Children's Hospital Case Western Reserve University School of Medicine  Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Gosiengfiao","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology &amp; Transplantation Robert Lurie Comprehensive Cancer Center Ann &amp; Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Hematology\u2010Oncology Texas Children's Hospital Baylor College of Medicine  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan E.","family":"Wickiser","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Children's Medical Center of Dallas University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Lindsay","family":"Frazier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Dana-Farber\/Boston Children's Cancer and Blood Disorders Center Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.03.026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.1006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513819009067110"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80297-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(75)90276-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90563-M"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90426-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0729-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199807)31:1<8::AID-MPO2>3.0.CO;2-H"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.7.2137"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-989399"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03889.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00317-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.7.1943"},{"issue":"6","key":"e_1_2_9_18_1","first-page":"33","article-title":"Non seminomatous GCT in children: final long term results of the French SFOP\/SFCE TGM 95 Protocol","volume":"59","author":"Patte C OD","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198101000-00012"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:05:57Z","timestamp":1696500357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/pbc.26311"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26311","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2016,10,27]]},"article-number":"e26311"}}