{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:15:01Z","timestamp":1791342901383,"version":"4.3.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["SUS0034\/2013"],"award-info":[{"award-number":["SUS0034\/2013"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Stroke is a severe clinical disorder in sickle cell disease (SCD), and few studies have evaluated transcranial Doppler (TCD) flow velocities in hemoglobin SC disease (HbSC). The guidelines for stroke risk are based on evaluations in sickle cell anemia (SCA) or HbS\/\u03b2 thalassemia.<\/jats:p><jats:p>Procedure: In this study, we compare cerebral blood flow in patients with SCD stratified by genotypes. A total of 1,664 pediatric patients with SCD underwent TCD velocity screening, and the time\u2010averaged maximum mean velocity (TAMM) was determined in the middle cerebral artery (MCA), anterior cerebral artery (ACA), and distal intracranial internal carotid artery (ICA).<\/jats:p><jats:p>Results: Abnormal velocities were not identified in the ACA; therefore, we only use ICA and MCA velocities. TAMM from the left and right in the ICA and MCA was 134.3 \u00b1 32.0 and 134.4 \u00b1 32.6 cm\/s in patients with SCA, and 105.2 \u00b1 20.6 and 104.7 \u00b1 20.0 cm\/s in the patients with HbSC, respectively. Mean TAMM between right and left ICA\/MCA was 134.5 \u00b1 30.5 cm\/s in the SCA group, and 104.9 \u00b1 19.3 cm\/s in the HbSC group. Notably, our data show that TCD velocities were significantly lower among the patients with HbSC compared to SCA. TAMM was negatively correlated with hemoglobin and hematocrit in both genotypes.<\/jats:p><jats:p>Conclusion: These results suggest that a different cut\u2010off value for abnormal TCD velocities could be considered for patients with HbSC. Additional studies are warranted to determine the actual risk of stroke in HbSC genotype associated with this possible TCD risk value.<\/jats:p>","DOI":"10.1002\/pbc.26342","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T05:52:57Z","timestamp":1481608377000},"source":"Crossref","is-referenced-by-count":12,"title":["Transcranial Doppler in hemoglobin SC disease"],"prefix":"10.1002","volume":"64","author":[{"given":"Camilo","family":"Vieira","sequence":"first","affiliation":[{"name":"Ambulat\u00f3rio Pedi\u00e1trico de Doen\u00e7a Cerebrovascular, Hospital Universit\u00e1rio Professor Edgard Santos Universidade Federal da Bahia  Bahia Brazil"},{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Nogueira Costa","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Salvador  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila Ara\u00fajo Borges","family":"de Figueiredo","sequence":"additional","affiliation":[{"name":"Universidade Salvador  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayra Pereira","family":"Santiago","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz  Bahia Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal da Bahia  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corynne Stephanie Ahouefa","family":"Adanho","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz  Bahia Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal da Bahia  Bahia 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Souza","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz  Bahia Brazil"},{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia Universidade Federal da Bahia  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/178792a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90023-X"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: Rates and risk factors","volume":"91","author":"Ohene\u2010Frempong 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