{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:13Z","timestamp":1790267053667,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:00:00Z","timestamp":1482537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["27\u20104"],"award-info":[{"award-number":["27\u20104"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with Down syndrome (DS) are predisposed to acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in early and later childhood, respectively, but rarely experience both. We herein discuss four patients with DS with ALL and a history of AML who were treated with various chemotherapies, one of whom later received a bone marrow transplantation. Three patients survived and remain in remission. One patient died of fulminant hepatitis during therapy. No common cytogenetic abnormalities in AML and ALL besides constitutional +21 were identified, indicating that the two leukemia types were independent events. However, the underlying pathomechanism of these conditions awaits clarification.<\/jats:p>","DOI":"10.1002\/pbc.26411","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T05:43:12Z","timestamp":1482644592000},"source":"Crossref","is-referenced-by-count":6,"title":["Acute lymphoblastic leukemia in patients with Down syndrome with a previous history of acute myeloid leukemia"],"prefix":"10.1002","volume":"64","author":[{"given":"Daisuke","family":"Tomizawa","sequence":"first","affiliation":[{"name":"Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Pediatrics Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Medical Center  Japanese Red Cross Nagoya First Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimikazu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Children's Cancer Center National Center for Child Health and Development  Tokyo Japan"},{"name":"Department of Hematology and Oncology Children's Medical Center  Japanese Red Cross Nagoya First Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asahikawa Medical University  Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05264-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.089425"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-509463"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000172223.04694.c4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3687"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-112920"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22217"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1182\/blood.V118.21.1506.1506","article-title":"Successful Abolition of Prophylactic Cranial Irradiation in Children with Non\u2010T Acute Lymphoblastic Leukemia (ALL) in the Japan Association of Childhood Leukemia Study (JACLS) ALL\u201002 Trial","volume":"118","author":"Hasegawa D","year":"2011","journal-title":"Blood"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000039"},{"key":"e_1_2_7_11_1","first-page":"100","article-title":"Myelogenous leukemia in children. 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