{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:15:28Z","timestamp":1785323728029,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u2010CA21765"],"award-info":[{"award-number":["P30\u2010CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["GM92666"],"award-info":[{"award-number":["GM92666"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01\u2010CA90246"],"award-info":[{"award-number":["R01\u2010CA90246"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited information is available regarding neurocognitive outcomes of children who experience seizures during treatment for acute lymphoblastic leukemia (ALL). Accordingly, the main objectives of this study were to determine the incidence and risk factors for treatment\u2010related seizures among children with ALL, and the neurocognitive outcomes associated with treatment\u2010related seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Prospective neuropsychological assessment and magnetic resonance imaging (MRI) were planned for all 498 patients with newly diagnosed ALL enrolled on the St. Jude Total Therapy XV (TOTXV) protocol at three time points. The study database was reviewed retrospectively to identify those with treatment\u2010related seizure. To assess neurocognitive changes associated with seizure, each patient with treatment\u2010related seizure was matched with two cohort patients without seizure for age at treatment, gender, race, and treatment intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients developed seizure, with a 2\u2010year cumulative risk of 3.82 \u00b1 0.86% (SE). No risk factors were identified to be associated with the development of seizure, with a possible exception of intensive chemotherapy used on the standard\/high\u2010risk arm as compared to the low\u2010risk arm. Neuropsychological performance of the seizure group, as compared to normative scores and nonseizure control cohort, indicated problems in attention, working memory, and processing speed. Cognitive deficits persisted 2 years after therapy, with additional declines in intellectual function observed. MRI indicated early neurotoxicity among the seizure group, as evidenced by greater leukoencephalopathy on initial examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment\u2010related seizures were associated with leukoencephalopathy and decreased neuropsychological performance. Prospective studies are needed to detect changes in neurocognitive status associated with long\u2010term functional impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26436","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T05:54:23Z","timestamp":1485582863000},"source":"Crossref","is-referenced-by-count":23,"title":["Neurocognitive outcomes among children who experienced seizures during treatment for acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"64","author":[{"given":"Stephanie L.","family":"Nassar","sequence":"first","affiliation":[{"name":"Mental Health and Behavioral Science Services James A. Haley Veterans\u2019 Hospital  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Conklin","sequence":"additional","affiliation":[{"name":"Department of Psychology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Ashford","sequence":"additional","affiliation":[{"name":"Department of Psychology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilburn E.","family":"Reddick","sequence":"additional","affiliation":[{"name":"Division of Translational Imaging Research St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Glass","sequence":"additional","affiliation":[{"name":"Division of Translational Imaging Research St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred H.","family":"Laningham","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Children's Hospital Central California  Madera California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Jeha","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Pathology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Pathology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1636"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1616"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.01.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511977633.036"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21869"},{"key":"e_1_2_9_7_1","unstructured":"National Cancer Institute at the National Institutes of Health. 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