{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:13:43Z","timestamp":1790050423757,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1DK104046"],"award-info":[{"award-number":["RO1DK104046"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 17\u2010year\u2010old male presented with acute hemolysis with stomatocytosis, elevated mean corpuscular hemoglobin concentration (MCHC), and osmotic gradient ektacytometry consistent with marked erythrocyte dehydration. Erythrocytes from both parents also demonstrated evidence of dehydration with elevated MCHC and abnormal ektacytometry, but neither to the degree of the patient. Genetic studies revealed the patient had hereditary xerocytosis (HX) due to a novel <jats:italic>PIEZO1<\/jats:italic> mutation inherited from his mother and hemoglobin C (HbC) trait inherited from his father. HbC trait accentuated the erythrocyte dehydration of HX. Coinheritance of interrelated disorders and\/or modifier alleles should be considered whenever severe erythrocyte dehydration is observed.<\/jats:p>","DOI":"10.1002\/pbc.26444","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T11:52:46Z","timestamp":1485345166000},"source":"Crossref","is-referenced-by-count":15,"title":["Hemoglobin C trait accentuates erythrocyte dehydration in hereditary xerocytosis"],"prefix":"10.1002","volume":"64","author":[{"given":"Elizabeth","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatrics George Washington University School of Medicine  Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin B.","family":"Voelkel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inova Fairfax Hospital  Falls Church Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Lezon\u2010Geyda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut"},{"name":"Departments of Pathology and Genetics University School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.12128"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2015.09.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-657957"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32835f6870"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-482489"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23799"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12357"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-422253"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199605000-00005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.1.124.124"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1182\/blood.V36.1.14.14","article-title":"Red cell lifespan in hemoglobin C disorders (with special reference to hemoglobin C trait)","volume":"36","author":"Prindle KH","year":"1970","journal-title":"Blood"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111867"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1996.tb01287.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv308"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-609362"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1182\/blood.V75.1.266.266","article-title":"Recurrent acute spleni sequestration crisis due to interacting genetic defects: Hemoglobin SC disease and hereditary spherocytosis","volume":"75","author":"Warkentin TE","year":"1990","journal-title":"Blood"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.466"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.531"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.467"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.10.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-675488"}],"container-title":["Pediatric Blood &amp; 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