{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:40:51Z","timestamp":1784644851312,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recently, studies in adults with acute promyelocytic leukemia (APL) showed high cure rates in low\u2010risk patients treated with all\u2010\n                    <jats:italic>trans<\/jats:italic>\n                    retinoid acid (ATRA) and arsenic trioxide (ATO), while toxicities were significantly reduced compared to the standard treatment with ATRA and chemotherapy. Here we report about first experience with 11 pediatric patients with low\u2010risk APL treated with ATRA and ATO. All patients stayed in molecular remission. All suffered from hyperleukocytosis. Two patients experienced reversible severe side effects. One suffered from osteonecroses at both femurs, seizures, as well as posterior reversible encephalopathy syndrome, the other patient had an abducens paresis.\n                  <\/jats:p>","DOI":"10.1002\/pbc.26461","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:26:45Z","timestamp":1485131205000},"source":"Crossref","is-referenced-by-count":35,"title":["First experience of the AML\u2010Berlin\u2010Frankfurt\u2010M\u00fcnster group in pediatric patients with standard\u2010risk acute promyelocytic leukemia treated with arsenic trioxide and all\u2010\n                    <i>trans<\/i>\n                    retinoid acid"],"prefix":"10.1002","volume":"64","author":[{"given":"Ursula","family":"Creutzig","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Hannover Medical School, Children's Hospital  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Dworzak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Bochennek","sequence":"additional","affiliation":[{"name":"Division for Pediatric Hematology and Oncology Johann Wolfgang Goethe\u2010University  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology University Medicine of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Flotho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University Medical Center  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology Saarland University  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Kontny","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Medical Faculty RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rossig","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Dr. von Hauner Children`s Hospital Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend","family":"von Stackelberg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology Charit\u00e9 University Medical Center Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jans\u2010Enno","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"von Neuhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"von Neuhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300874"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-699439"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00193-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.3453"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-230805"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.5031"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21510"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0768-0"},{"issue":"7","key":"e_1_2_6_10_1","first-page":"454","article-title":"Can As2O3 improve the prognosis of childhood acute promyelocytic leukemia? 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