{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:05:39Z","timestamp":1770818739547,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This retrospective analysis comprises 10\u2010year experience with early posttransplant mixed chimerism\u2010based preemptive intervention. Out of 104 patients, 51 received preemptive immunotherapy. Their outcomes were similar to patients achieving full donor chimerism spontaneously. Among patients receiving intervention, 5\u2010year event\u2010free survival was identical in patients with and without pretransplant residual disease, respectively (68% [95% confidence interval (CI) 38\u201398%] vs. 69% [95% CI 54\u201385%] log\u2013rank = 0.4). In patients who received preemptive immunotherapy, chimerism status and residual disease prior to transplant were no longer predictors of poor outcome; however, 41% of the patients with residual disease prior to transplant relapsed early and did not benefit from this strategy.<\/jats:p>","DOI":"10.1002\/pbc.26464","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T06:12:46Z","timestamp":1487225566000},"source":"Crossref","is-referenced-by-count":12,"title":["Early mixed chimerism\u2010based preemptive immunotherapy in children undergoing allogeneic hematopoietic stem cell transplantation for acute leukemia"],"prefix":"10.1002","volume":"64","author":[{"given":"Biljana","family":"Horn","sequence":"first","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin T.","family":"Wahlstrom","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Melton","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Liou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Ouachee\u2010Chardin","sequence":"additional","affiliation":[{"name":"Immuno\u2010Hematology Unit Robert Debre Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri","family":"Sunkersett","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Willert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Hwang","sequence":"additional","affiliation":[{"name":"UCSF Helen Diller Family Comprehensive Cancer Center  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jueleah","family":"Expose\u2010Spencer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mort C.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janelle","family":"Facchino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Dvorak","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Bone Marrow Transplantation at University of California San Francisco (UCSF) Benioff Children's Hospital  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.09.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-535716"},{"key":"e_1_2_8_4_1","first-page":"3501","article-title":"IgH\u2010V(D)J NGS\u2010MRD measurement","volume":"125","author":"Pulsifer M","year":"2015","journal-title":"Blood"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-506725"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.198"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348805"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.03.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.39"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.339"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380386"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.133"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403719"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12639"},{"key":"e_1_2_8_16_1","first-page":"825","article-title":"1994 consensus conference on acute GVHD grading","volume":"15","author":"Prezpiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215134"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:17:01Z","timestamp":1696497421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/pbc.26464"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26464","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]},"article-number":"e26464"}}