{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:23:45Z","timestamp":1791915825271,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008628","name":"Institut for Klinisk Medicin, Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic significance of extramedullary leukemia (EML) in childhood acute myeloid leukemia is not clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This population\u2010based study included 315 children from the NOPHO\u2010AML 2004 trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At diagnosis, 73 (23%) patients had EML: 39 (12%) had myeloid sarcoma, 22 (7%) had central nervous system disease, and 12 (4%) had both. EML was associated with young age (median age: 2.6 years), a high white blood cell count (median: 40 \u00d7 10<jats:sup>9<\/jats:sup>\/l), M5 morphology (40%), and 11q23\/<jats:italic>MLL<\/jats:italic> (<jats:italic>KMT2A<\/jats:italic>) rearrangements (34%). No patient received involved field radiotherapy. Five\u2010year event\u2010free survival did not differ significantly between the EML and the non\u2010EML patients (54% vs. 45%, <jats:italic>P<\/jats:italic> = 0.57), whereas 5\u2010year overall survival (OS) was significantly lower in the EML group (64% vs. 73%, <jats:italic>P<\/jats:italic> = 0.04). The risk of induction death was significantly higher for EML patients (8% vs. 1%, <jats:italic>P<\/jats:italic> = 0.002). There was a trend toward a lower risk of relapse for EML patients (5\u2010year cumulative incidence of relapse 33% vs. 49%, <jats:italic>P<\/jats:italic> = 0.16). Traumatic lumbar puncture did not adversely affect survival in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EML was associated with increased risk of induction death impacting the OS. No patients relapsed at the primary site of the myeloid sarcoma despite management without radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26520","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T09:10:51Z","timestamp":1490346651000},"source":"Crossref","is-referenced-by-count":52,"title":["Extramedullary leukemia in children with acute myeloid leukemia: A population\u2010based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO)"],"prefix":"10.1002","volume":"64","author":[{"given":"Heidi Kristine","family":"St\u00f8ve","sequence":"first","affiliation":[{"name":"Department of Pediatrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Damgaard","family":"Sandahl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aarhus University Hospital  Aarhus 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