{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:23:59Z","timestamp":1783178639033,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T00:00:00Z","timestamp":1492128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood & Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>123<\/jats:sup>I\u2010meta\u2010iodo benzyl guanidine (MIBG) scans are considered the gold standard imaging in neuroblastoma; however, flouro deoxy glucose positron emission tomography (FDG\u2010PET) scans have increased sensitivity in adults with pheochromocytoma\/paraganglioma. We describe a pediatric patient initially considered to have localized neuroblastoma based on anatomical imaging and 123<\/jats:sup>I\u2010MIBG scan, but subsequent investigations revealed germline succinate dehydrogenase complex iron sulfur subunit B (SDHB) mutation\u2013associated pheochromocytoma with multiple FDG\u2010avid skeletal metastases. We then compared 123<\/jats:sup>I\u2010MIBG and FDG\u2010PET scans in children with metastatic pheochromocytoma\/paraganglioma. FDG\u2010PET was superior to 123<\/jats:sup>I\u2010MIBG scan for the detection of skeletal metastases (median number of skeletal lesions detected 10 [range 1\u201330] vs. 2 [range 1\u201326], respectively; P<\/jats:italic> = 0.005 by t\u2010test). FDG\u2010PET should be considered the functional scan of choice in children with pheochromocytoma\/paraganglioma.<\/jats:p>","DOI":"10.1002\/pbc.26549","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T09:02:59Z","timestamp":1492160579000},"source":"Crossref","is-referenced-by-count":8,"title":["Failure of MIBG scan to detect metastases in SDHB\u2010mutated pediatric metastatic pheochromocytoma"],"prefix":"10.1002","volume":"64","author":[{"given":"Sameer","family":"Sait","sequence":"first","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Centre New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Pandit\u2010Taskar","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Radiology Memorial Sloan Kettering Cancer Centre New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Modak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Centre New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020152"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2352"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03648.x"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"419","article-title":"Detection and treatment of pheochromocytomas and paragangliomas: current standing of MIBG scintigraphy and future role of PET imaging","volume":"52","author":"Havekes B","year":"2008","journal-title":"Q J Nucl Med Mol Imag"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2215-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0415"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP15725.OR"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2010.11.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020525"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6297"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1248"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030235"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs188"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-07-0217"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"122","article-title":"Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work\u2010up of pheochromocytoma and paraganglioma: a systematic review","volume":"57","author":"Rufini V","year":"2013","journal-title":"Q J Nucl Med Mol Imag"}],"container-title":["Pediatric Blood & Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:37:20Z","timestamp":1696477040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,14]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/pbc.26549"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26549","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,14]]},"article-number":"e26549"}}