{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:13:17Z","timestamp":1782882797469,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In childhood acute lymphoblastic leukemia (ALL), t(1;19)(q23;p13.3) with <jats:italic>TCF3\u2010PBX1<\/jats:italic> fusion is one of the most frequent translocations. Historically, it has been associated with poor prognosis. Intensive treatment, however, has improved its outcome. We determined the outcome of children with this genotype treated with contemporary intensive chemotherapy in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>In Taiwan Pediatric Oncology Group 2002 ALL studies, genotypes were determined by cytogenetic analysis and\/or reverse transcriptase polymerase chain reaction assay. Based on presenting features, immunophenotype and genotype, patients were assigned to one of the three risk groups: standard risk (SR), high risk (HR), or very high risk (VHR). The patients with t(1;19)\/<jats:italic>TCF3\u2010PBX1<\/jats:italic> were treated in the HR arm receiving more intensive chemotherapy. The outcomes of patients with t(1;19)\/<jats:italic>TCF3\u2010PBX1<\/jats:italic> were compared to that of patients with other subtypes of B\u2010precursor ALL (B\u2010ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1,129 patients with B\u2010ALL, 64 (5.7%) had t(1;19)\/<jats:italic>TCF3\u2010PBX1<\/jats:italic>; 51 of whom were treated in the HR arm, but 11 were treated in the VHR and 2 in the SR arm because of physician's preference. As a group, 64 patients with t(1;19)\/<jats:italic>TCF3\u2010PBX1<\/jats:italic> had similar 5\u2010year event\u2010free survival (83.3 \u00b1 4.8%) as those with <jats:italic>TEL\u2010AML1<\/jats:italic> (85.2 \u00b1 3.4%, <jats:italic>P<\/jats:italic> = 0.984) or those with hyperdiploidy &gt;50 (84.0 \u00b1 3.1%, <jats:italic>P<\/jats:italic> = 0.748). The cumulative risk of any (isolated plus combined) central nervous system relapse among patients with t(1;19)\/<jats:italic>TCF3\u2010PBX1<\/jats:italic> (8.7 \u00b1 3.8%) tended to be higher than that of patients with <jats:italic>TEL\u2010AML1<\/jats:italic> (5.8 \u00b1 2.3%, <jats:italic>P<\/jats:italic> = 0.749) or those with hyperdiploidy (4.1 \u00b1 1.8%, <jats:italic>P<\/jats:italic> = 0.135), albeit the differences did not reach statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With contemporary intensive chemotherapy, children with t(1;19)\/<jats:italic>TCF3\u2010PBX1<\/jats:italic> fared as well as those with favorable genotypes (<jats:italic>TEL\u2010AML1<\/jats:italic> or hyperdiploidy).<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26557","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T12:26:02Z","timestamp":1493036762000},"source":"Crossref","is-referenced-by-count":15,"title":["Pediatric acute lymphoblastic leukemia with t(1;19)\/<i>TCF3\u2010PBX1<\/i> in Taiwan"],"prefix":"10.1002","volume":"64","author":[{"given":"Hsiu\u2010Ju","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Taipei Veterans General Hospital and School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Department of Life Science National Taiwan Normal University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hsiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2013Oncology Chang Gung Children's Hospital\u2013Linkou  Taoyuan 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Hemato\/Oncology Children's Hospital of China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Chi","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mackay Memorial Hospital, and Mackay Medical College  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Chung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Koo Foundation Sun\u2010Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei 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