{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:20:13Z","timestamp":1788081613965,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"C17 Council and the support they receive from Childhood Cancer Canada Foundation and Coast to Coast Against Cancer Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to generate, optimize, and validate a self\u2010administered pediatric bleeding questionnaire (Self\u2010PBQ) as a screening tool for von Willebrand disease (VWD) in children referred to the hematology clinic for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>The Self\u2010PBQ was generated by combining the validated expert\u2010administered PBQ and the International Society on Thrombosis and Hemostasis (ISTH) bleeding assessment tool (BAT). Medical terminology was translated into lay language requiring a grade 4 reading level. In Phase 1, the Self\u2010PBQ was optimized and the level of agreement between the Self\u2010PBQ and the expert\u2010administered PBQ was determined. Phase 2 established the normal range of bleeding scores (BSs) of the Self\u2010PBQ. Phase 3 examined the Self\u2010PBQ as a screening tool for first\u2010time referrals to the hematology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Self\u2010PBQ is a reliable surrogate for the expert\u2010administered PBQ with an excellent intraclass correlation (ICC) of 0.917. The Self\u2010PBQ was scored with the PBQ and the ISTH\u2010BAT scoring systems, for which its normal BS ranges are \u20131 to 2 or 0 to 2, respectively. A positive Self\u2010PBQ BS (\u22653) had a sensitivity of 78%, a specificity of 37%, a positive predictive value of 0.18, and a negative predictive value of 0.91 for identifying VWD in children being investigated by a hematologist for a bleeding disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Self\u2010PBQ generates comparable BSs to the expert\u2010administered PBQ and is a reliable, reasonably sensitive screening tool to incorporate into the assessment of children presenting to a hematologist for the investigation of an inherited bleeding disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26588","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T13:14:46Z","timestamp":1493385286000},"source":"Crossref","is-referenced-by-count":22,"title":["Generation and optimization of the self\u2010administered pediatric bleeding questionnaire and its validation as a screening tool for von Willebrand disease"],"prefix":"10.1002","volume":"64","author":[{"given":"Lara J.","family":"Casey","sequence":"first","affiliation":[{"name":"Queen's University  Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Tuttle","sequence":"additional","affiliation":[{"name":"Queen's University  Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Grabell","sequence":"additional","affiliation":[{"name":"Queen's University  Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Hopman","sequence":"additional","affiliation":[{"name":"Queen's University  Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Moorehead","sequence":"additional","affiliation":[{"name":"Janeway Children's Health and Rehabilitation Centre  St. John's Canada"},{"name":"Discipline of Pediatrics Faculty of Medicine Memorial University  St. John's Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor S.","family":"Blanchette","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics University of Toronto Hospital for Sick Children  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Wu","sequence":"additional","affiliation":[{"name":"British Columbia Children's Hospital  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MacGregor","family":"Steele","sequence":"additional","affiliation":[{"name":"Alberta Children's Hospital  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Silva","sequence":"additional","affiliation":[{"name":"Queen's University  Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Rand","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Program in Experimental Medicine The Hospital for Sick Children"},{"name":"Departments of Laboratory Medicine &amp; 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