{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:54:46Z","timestamp":1768002886282,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006459","name":"Children's Hospital Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The adverse effects of irradiation on endocrine function among patients with pediatric brain tumor are well documented. Intensive induction chemotherapy followed by marrow\u2010ablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) without central nervous system (CNS) irradiation has demonstrated efficacy in a proportion of very young children with some malignant CNS tumors. This study assessed the long\u2010term endocrine function of young children following chemotherapy\u2010only treatment regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A retrospective chart review was performed on 99 patients under 6 years of age with malignant brain tumors newly diagnosed between May 1991 and October 2010 treated with irradiation\u2010avoiding strategies. Thirty patients survived post\u2010AuHCR without cranial irradiation for a mean of 8.1 years (range 3.0\u201322.25 years). The patient cohort included 18 males and 12 females (mean age at AuHCR of 2.5 years, range 0.8\u20135.1 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 30 surviving patients had documented normal age\u2010related thyroid function, insulin\u2010like growth factor binding protein 3 (IGF\u2010BP3), prolactin, testosterone, and estradiol levels. Insulin\u2010like growth factor 1 age\u2010related levels were abnormal in one child with normal height. Ninety\u2010seven percent of patients had normal cortisol levels, while follicle\u2010stimulating hormone and LH levels among females were normal in 83% and 92%, respectively, and in 100% of males. Growth charts demonstrated age\u2010associated growth within 2 standard deviations of the mean in 67% of patients. Of 10 patients (33%) with short stature, 6 had proportional diminutions in both height and weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate that the use of relatively brief, intensive chemotherapy regimens including marrow\u2010ablative chemotherapy with AuHCR results in fewer endocrine sequelae than treatment schemes utilizing CNS irradiation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26616","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T14:23:14Z","timestamp":1493994194000},"source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term follow\u2010up of endocrine function among young children with newly diagnosed malignant central nervous system tumors treated with irradiation\u2010avoiding regimens"],"prefix":"10.1002","volume":"64","author":[{"given":"Anne M.","family":"Cochrane","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Children's Hospital Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Children's Hospital Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasey","family":"Rangan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Children's Hospital Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Freyer","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Children's Hospital Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Nahata","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Nationwide Children's Hospital and The Ohio State University  Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Dhall","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Children's Hospital Los Angeles  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Finlay","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and BMT Nationwide Children's Hospital and The Ohio State University  Columbus 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