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Here, we report the case of a patient with NF1 who developed synchronous malignant peripheral nerve sheath tumors, one with a focus of angiosarcoma. He succumbed to metastatic angiosarcoma despite local resection and adjuvant chemotherapy. This case highlights the need for monitoring for malignancy in NF1 patients, the risks of sampling error during tumor biopsy, and the clinical decision \u2010 making involved in choosing a therapeutic plan for a patient with multiple simultaneous malignancies.<\/jats:p>","DOI":"10.1002\/pbc.26643","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T13:37:36Z","timestamp":1495805856000},"source":"Crossref","is-referenced-by-count":5,"title":["Metastatic angiosarcoma arising in malignant peripheral nerve sheath tumor in a young patient with neurofibromatosis type 1"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-7505","authenticated-orcid":false,"given":"Amanda C.","family":"Winters","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT University of Colorado School of Medicine and Children's Hospital Colorado  Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer O.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Colorado School of Medicine and Children's Hospital Colorado  Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrye R.","family":"Cost","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT University of Colorado School of Medicine and Children's Hospital Colorado  Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.5.311"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-6-477"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.4886"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840915)54:6<1049::AID-CNCR2820540620>3.0.CO;2-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90040-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00714.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920901)70:5<1141::AID-CNCR2820700519>3.0.CO;2-Q"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24668"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24755"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm450"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-009-0045-z"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.41.5.474"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90866-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26599"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr138"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31827e4e7b"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.10.004"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0569-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1234068"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:55:39Z","timestamp":1695977739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,26]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/pbc.26643"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26643","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,26]]},"article-number":"e26643"}}