{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:21:50Z","timestamp":1790446910503,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T00:00:00Z","timestamp":1499472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Municipal Science and Technology Commission of the capital special funding support","award":["Z151100004015159"],"award-info":[{"award-number":["Z151100004015159"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pleuropulmonary blastoma (PPB) is the most common primary malignant neoplasm of the lung in children that is associated with a germline mutation in <jats:italic>DICER1<\/jats:italic>. In this report, we share an interesting case of a pair of monozygotic twins: one of them developed PPB when she was 4\u2010year old, while the other developed acute transient hepatitis when she was 5\u2010year old. Next\u2010Gen sequencing for <jats:italic>DICER1<\/jats:italic> mutations of their family revealed that both twins and their mother had <jats:italic>c.C3675A<\/jats:italic> mutation. The mother also had a history of multinodular goiter. Identification of <jats:italic>DICER1<\/jats:italic> mutation carriers and close surveillance of individuals at risk for <jats:italic>DICER1<\/jats:italic> syndrome may allow early detection and hence better outcome.<\/jats:p>","DOI":"10.1002\/pbc.26680","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T07:56:40Z","timestamp":1499500600000},"source":"Crossref","is-referenced-by-count":4,"title":["A pair of DICER1\u2010positive monozygotic twins: One with pleuropulmonary blastoma, another with acute transient hepatitis"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-6767","authenticated-orcid":false,"given":"Sihui","family":"Li","sequence":"first","affiliation":[{"name":"Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education MOE Key Laboratory of Major Diseases in Children  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Evidence\u2010Based Medicine Beijing Children's Hospital Capital Medical University Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xisi","family":"Wang","sequence":"additional","affiliation":[{"name":"Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education MOE Key Laboratory of Major Diseases in Children  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education MOE Key Laboratory of Major Diseases in Children  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libing","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Children's Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Thoracic Surgery Beijing Children's Hospital Capital Medical University Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology and Evidence\u2010Based Medicine Beijing Children's Hospital Capital Medical University Key Laboratory of Major Diseases in Children Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ma","sequence":"additional","affiliation":[{"name":"Hematology Oncology Center Beijing Children's Hospital Capital Medical University Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics Ministry of Education MOE Key Laboratory of Major Diseases in Children  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25092"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2350\/15-10-1732-OA.1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23047"},{"key":"e_1_2_6_5_1","first-page":"312","article-title":"Case report of a 3\u2010year\u2010old gril with pleuropulmonary blastoma and family history of a tumor predisposition syndrome with c. 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