{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:49:29Z","timestamp":1781552969435,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["DP5 OD021403"],"award-info":[{"award-number":["DP5 OD021403"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild\u2010type tumor was <jats:italic>MGMT<\/jats:italic> methylated and contained an <jats:italic>ATRX<\/jats:italic> mutation, <jats:italic>BRAF<\/jats:italic> alteration, and 1p\/19q co\u2010deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.<\/jats:p>","DOI":"10.1002\/pbc.26708","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T12:17:34Z","timestamp":1499775454000},"source":"Crossref","is-referenced-by-count":6,"title":["Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature"],"prefix":"10.1002","volume":"64","author":[{"given":"Caryn","family":"Sorge","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's of Alabama  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's of Alabama  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa T.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-7420","authenticated-orcid":false,"given":"Gregory K.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0674-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402121"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor146"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2611"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1539-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.3414"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000610"},{"issue":"5","key":"e_1_2_7_9_1","first-page":"699","article-title":"Targeted next\u2010generation sequencing of pediatric neuro\u2010oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy","volume":"19","author":"Kline CN","year":"2017","journal-title":"Neuro\u2010oncology"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.5.530"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000221"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12291"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.2229"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.2674"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.3891"},{"issue":"5","key":"e_1_2_7_16_1","first-page":"500","article-title":"A phase II trial of primary temozolomide in patients with grade III olidenodroglial brain tumors","volume":"12","author":"Gan HK","year":"2010","journal-title":"Neuro Oncol"}],"container-title":["Pediatric Blood &amp; 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