{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:38:41Z","timestamp":1788910721831,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment\u2010related toxicity and mortality are not uncommon during maintenance chemotherapy for childhood acute lymphoblastic leukemia (ALL), especially in the low\u2010 and middle\u2010income countries (LMIC). Undernutrition and micronutrient deficiencies are commonly seen in children from LMICs undergoing treatment for ALL. The present study examines the prevalence and clinical implications of folate deficiency in north Indian children with ALL during the maintenance phase of treatment in view of prolonged antifolate treatment and high population prevalence of folate deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Pre\u2010cycle folate levels\/deficiency as well as weight for age <jats:italic>z<\/jats:italic>\u2010score and serum albumin level were determined and correlated with complications of treatment and mortality encountered during the maintenance phase of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010nine of 52 children enrolled in the study had folate deficiency at some point during maintenance chemotherapy. Neutropenia (18 of 29 vs. 4 of 23; <jats:italic>P<\/jats:italic> = 0.002), thrombocytopenia (17 of 29 vs. 4 of 23; <jats:italic>P<\/jats:italic> = 0.005), febrile neutropenia (17 of 29 vs. 4 of 23; <jats:italic>P<\/jats:italic> = 0.005), and need for chemotherapy dose reduction (20 of 29 vs. 7 of 21; <jats:italic>P<\/jats:italic> = 0.01) were more common in folate\u2010deficient children. Maintenance deaths were higher (8 of 29 vs. 1 of 23; <jats:italic>P<\/jats:italic> = 0.03) and survival lower (<jats:italic>P<\/jats:italic> = 0.02) in deficient children. In multivariate analysis, hypoalbuminemia (<jats:italic>P<\/jats:italic> = 0.02) and folate deficiency (<jats:italic>P<\/jats:italic> = 0.01) were associated with febrile neutropenia, and folate deficiency with maintenance deaths (<jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Folate deficiency was associated with treatment\u2010related complications and adverse outcome in our patients. The risks and benefits of folate supplementation in deficient children during maintenance chemotherapy need to be explored with properly designed randomized studies in similar settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26730","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T09:49:27Z","timestamp":1501667367000},"source":"Crossref","is-referenced-by-count":8,"title":["Folate deficiency in north Indian children undergoing maintenance chemotherapy for acute lymphoblastic leukemia\u2014Implications and outcome"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5650-3115","authenticated-orcid":false,"given":"Nirmalya","family":"Roy Moulik","sequence":"first","affiliation":[{"name":"Department of Paediatrics Royal Marsden Hospital  Sutton Greater London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics King George's Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraksha","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Ali","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry King George's Medical University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,2]]},"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:51:47Z","timestamp":1696035107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/pbc.26730"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26730","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"article-number":"e26730"}}