{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:19:25Z","timestamp":1791652765364,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      About 10% of patients with neurofibromatosis type 1 (NF\u20101) develop malignant peripheral nerve sheath tumours (MPNST) mostly arising in plexiform neurofibroma (PN); 15% of MPNST arise in children and adolescents. 2\u2010[\n                      <jats:sup>18<\/jats:sup>\n                      F]fluoro\u20102\u2010deoxy\u2010d\u2010glucose ([\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG)\u2010PET (where PET is positron emission tomography) is a sensitive method in differentiating PN and MPNST in symptomatic patients with NF\u20101. This study assesses the value of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG\u2010PET imaging in detecting malignant transformation in symptomatic and asymptomatic children with PN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one patients with NF\u20101 and extensive PN underwent prospective [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG imaging from 2003 to 2014. Thirty\u2010two of the patients were asymptomatic. PET data, together with histological results and clinical course were re\u2010evaluated retrospectively. Maximum standardised uptake values (SUVmax) and lesion\u2010to\u2010liver ratio were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 104 examinations were performed. Mean age at first PET was 13.5 years (2.6\u201322.6). Eight patients had at least one malignant lesion; four of these patients were asymptomatic. Two of four symptomatic patients died, while all patients with asymptomatic malignant lesions are alive. All malignant tumours could be identified by PET imaging in both symptomatic and asymptomatic patients. All lesions judged as benign by [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG imaging and clinical judgment were either histologically benign if removed or remained clinically silent during follow\u2010up. SUVmax of malignant and benign lesions overlapped, but no malignant lesion showed FDG uptake \u22643.15. Asymptomatic malignant lesions were detected with a sensitivity of 100%, a negative predictive value of 100% and a specificity of 45.1%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Malignant transformation of PN also occurs in asymptomatic children and adolescents. Detection of MPNST at early stages could increase the possibility of oncologically curative resections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.26733","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T16:22:21Z","timestamp":1501777341000},"source":"Crossref","is-referenced-by-count":49,"title":["Monitoring of plexiform neurofibroma in children and adolescents with neurofibromatosis type 1 by [\n                    <sup>18<\/sup>\n                    F]FDG\u2010PET imaging. Is it of value in asymptomatic patients?"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-6644","authenticated-orcid":false,"given":"Amedeo A.","family":"Azizi","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Slavc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Emile","family":"Theisen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Rausch","sequence":"additional","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Happak","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Aszmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Hojreh","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Peyrl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Amann","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Benkoe","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wadsak","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Kasprian","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Staudenherz","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Traub\u2010Weidinger","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine Department of Biomedical Imaging and Image\u2010Guided Therapy Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<1::AID-AJMG3>3.0.CO;2-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1653"},{"key":"e_1_2_8_4_1","unstructured":"National Institutes of Health Consensus Development Conference Statement: neurofibromatosis. Bethesda MD USA July 13\u201315 1987.Neurofibromatosis.1988;1(3):172\u2013178 https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3152465?report=docsum&format=text"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20289"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.5.311"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3329-2-17"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.216"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"1957","article-title":"Malignant peripheral nerve sheath tumors (MPNST) in NF1\u2010affected children","volume":"27","author":"Friedrich RE","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3204"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000828)93:5<388::AID-AJMG8>3.0.CO;2-#"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168830.79997.13"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1293-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.04.008"},{"key":"e_1_2_8_15_1","article-title":"Usefulness of whole\u2010body fluorine\u201018\u2010fluorodeoxyglucose positron emission tomography in patients with neurofibromatosis type 1: a systematic review","volume":"2012","author":"Treglia G","year":"2012","journal-title":"Radiol Res Pract"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.044628"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24755"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318266ce84"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1386-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0840-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9501-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0799-9"},{"issue":"2","key":"e_1_2_8_23_1","first-page":"235","article-title":"Efficient stereospecific synthesis of no\u2010carrier\u2010added 2\u2010[18F]\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose using aminopolyether supported nucleophilic substitution","volume":"27","author":"Hamacher K","year":"1986","journal-title":"J Nucl Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2060"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm450"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000337597.18599.D3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24212"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2314-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-1038-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3413\/Nukmed-0665-14-05"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2010.12.003"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0954-z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000447"},{"key":"e_1_2_8_34_1","first-page":"784","volume-title":"Enzinger & Weiss's Soft Tissue Tumors","author":"Goldblum J","year":"2014"},{"key":"e_1_2_8_35_1","first-page":"855","volume-title":"Enzinger & Weiss's Soft Tissue Tumors","author":"Goldblum J","year":"2014"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24929"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1293-1"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.3.353"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-0030-1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(03)00055-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.142372"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.142372"},{"key":"e_1_2_8_43_1","first-page":"6162182","article-title":"The role of [18F]FDG\u2010PET\/CT in predicting malignant transformation of plexiform neurofibromas in neurofibromatosis\u20101","volume":"2016","author":"Tovmassian D","year":"2016","journal-title":"Int J Surg Oncol"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2295-5"},{"issue":"1","key":"e_1_2_8_45_1","first-page":"5","article-title":"Staging and response assessment in lymphomas: the new Lugano classification","volume":"4","author":"Cheson BD.","year":"2015","journal-title":"Chin Clin Oncol"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2715-9"},{"issue":"5","key":"e_1_2_8_47_1","first-page":"v151","article-title":"18F\u2010FDG PET and PET \/ CT monitoring of plexiform neurofibroma in children and adolescents with neurofibromatosis type 1","volume":"17","author":"Azizi AA","year":"2015","journal-title":"Neuro\u2010Oncology"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1297-4"},{"issue":"4","key":"e_1_2_8_49_1","first-page":"608","article-title":"Radiation exposure of patients undergoing whole\u2010body dual\u2010modality 18F\u2010FDG PET\/CT examinations","volume":"46","author":"Brix G","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-008-1015-6"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(92)90054-L"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<1937::AID-CNCR2820571008>3.0.CO;2-W"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90240-M"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03038185"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90156-1"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00510059"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.065912"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-007-0732-6"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4905045"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:52:07Z","timestamp":1696020727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,3]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/pbc.26733"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26733","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,3]]},"article-number":"e26733"}}