{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:05:47Z","timestamp":1762459547759,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T00:00:00Z","timestamp":1502496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low bone mass is common among adolescents with transfusion\u2010dependent \u03b2\u2010thalassemia despite adequate transfusion and iron chelation. However, there are few reports regarding bone mineral density (BMD) among adolescents with nontransfusion\u2010dependent thalassemia (NTDT). Indeed, only BMD data in patients with nontransfusion\u2010dependent (NTD) \u03b2\u2010thalassemia intermedia have been reported. No previous study has investigated BMD among adolescents with NTD hemoglobin (Hb) E\/\u03b2\u2010thalassemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of low bone mass among adolescents with NTD Hb E\/\u03b2\u2010thalassemia and factors relating to low bone mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated BMD of lumbar spine (L2\u2013L4; BMDLS) and total body (BMDTB), as measured by dual\u2010energy X\u2010ray absorptiometry, in 22 adolescents (aged 13.2\u201320 years) with NTD Hb E\/\u03b2\u2010thalassemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low bone mass was found to be 18.2% and 22.7% at the lumbar spine (BMDLS Z\u2010score adjusted for bone age and height age) and 13.6% and 9.1% at the total body (BMDTB Z\u2010score adjusted for bone age and height age). Patients with mean Hb level &lt;8 g\/dl were more likely to have low bone mass (BMDLS and BMDTB Z\u2010scores adjusted for bone age) compared to those with Hb level \u2265 8 g\/dl. Mean Hb level correlated with BMDLS and BMDTB Z\u2010scores adjusted for bone age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that a low Hb level was associated with low bone mass among adolescents with NTD Hb E\/\u03b2\u2010thalassemia. A significant proportion of low bone mass among these patients highlights the importance of appropriate management, including red cell transfusion, vitamin D and calcium supplementation for improved long\u2010term bone health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26744","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T07:52:40Z","timestamp":1502524360000},"source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of low bone mass among adolescents with nontransfusion\u2010dependent hemoglobin E\/\u03b2\u2010thalassemia and its relationship with anemia severity"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-5071","authenticated-orcid":false,"given":"Pairunyar","family":"Nakavachara","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Faculty of Medicine Siriraj Hospital Department of Pediatrics Mahidol University  Bangkok 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