{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:00:00Z","timestamp":1790704800228,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002276","name":"Pediatric Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08 CA072868"],"award-info":[{"award-number":["K08 CA072868"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010risk and recurrent medulloblastoma (MB) is associated with significant mortality. The murine monoclonal antibody 3F8 targets the cell\u2010surface disialoganglioside GD2 on MB. We tested the efficacy, toxicity, and dosimetry of compartmental radioimmunotherapy (cRIT) with intraventricular <jats:sup>131<\/jats:sup>I\u2010labeled 3F8 in patients with MB on a phase II clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with histopathologically confirmed high\u2010risk or recurrent MB were eligible for cRIT. After determining adequate cerebrospinal fluid (CSF) flow, patients received 2\u00a0mCi (where Ci is Curie) <jats:sup>124<\/jats:sup>I\u20103F8 or <jats:sup>131<\/jats:sup>I\u20103F8 with nuclear imaging for dosimetry, followed by up to four therapeutic (10\u00a0mCi\/dose) <jats:sup>131<\/jats:sup>I\u20103F8 injections. Dosimetry estimates were based on serial CSF and blood samplings over 48 hr plus region\u2010of\u2010interest analyses on serial imaging scans. Disease evaluation included pre\u2010 and posttherapy brain\/spine magnetic resonance imaging approximately every 3 months for the first year after treatment, and every 6\u201312 months thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three patients received a total of 167 injections; 42 patients were evaluable for outcome. No treatment\u2010related deaths occurred. Toxicities related to drug administration included acute bradycardia with somnolence, headache, fatigue, and CSF pleocytosis consistent with chemical meningitis and dystonic reaction. Total CSF absorbed dose was 1,453 cGy (where Gy is Gray; 350.0\u20132,784). Median overall survival from first dose of cRIT was 24.9 months (95% confidence interval [CI]:16.3\u201355.8). Patients treated in radiographic and cytologic remission were at a lower risk of death compared to patients with radiographically measurable disease (hazard ratio: 0.40, 95% CI: 0.18\u20130.88, <jats:italic>P<\/jats:italic> = 0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>cRIT with <jats:sup>131<\/jats:sup>I\u20103F8 is safe, has favorable dosimetry to CSF, and when added to salvage therapy using conventional modalities, may have clinical utility in maintaining remission in high\u2010risk or recurrent MB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26754","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T03:22:37Z","timestamp":1506136957000},"source":"Crossref","is-referenced-by-count":73,"title":["A phase II study of radioimmunotherapy with intraventricular <sup>131<\/sup>I\u20103F8 for medulloblastoma"],"prefix":"10.1002","volume":"65","author":[{"given":"Kim","family":"Kramer","sequence":"first","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Pandit\u2010Taskar","sequence":"additional","affiliation":[{"name":"Department of Radiology (Molecular Imaging and Therapy Service) Memorial Sloan Kettering Cancer Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Humm","sequence":"additional","affiliation":[{"name":"Department of Radiology (Molecular Imaging and Therapy Service) Memorial Sloan Kettering Cancer Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat B.","family":"Zanzonico","sequence":"additional","affiliation":[{"name":"Department of Radiology (Molecular Imaging and Therapy Service) Memorial Sloan Kettering Cancer Center  New 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A.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Weill Cornell Medical College  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Radiology (Molecular Imaging and Therapy Service) Memorial Sloan Kettering Cancer Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge K.","family":"Lyashchenko","sequence":"additional","affiliation":[{"name":"Department of Radiology (Molecular Imaging and Therapy Service) Memorial Sloan Kettering Cancer Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Khakoo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge 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