{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:06:04Z","timestamp":1780380364411,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T00:00:00Z","timestamp":1502496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify characteristics of pediatric sickle cell disease (SCD) hospitalizations and to examine admission demographics and medical expenditures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Admissions with SCD were identified from the 2009 and 2012 releases of the Healthcare and Cost Utilization Project's Kids Inpatient Database. Disease\u2010specific secondary diagnoses including acute chest syndrome (ACS), vaso\u2010occlusive pain crisis (VOC), splenic sequestration, and stroke\/transient ischemic attack were analyzed for patient and hospital demographics. Analytical endpoints included total healthcare expenditures and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We reviewed 75,234 inpatient hospitalizations with a diagnosis of SCD. Over $900,000,000 was spent annually in associated healthcare expenditure. The median length of hospitalization stay (LOS) for all admissions was 3 days (interquartile range [IQR] 2\u20135 days). VOC was the most frequent secondary diagnosis, recording 48,698 total hospitalizations and a median LOS of 3 days (IQR 2\u20136 days). Of the 8,490 hospitalizations with ACS, the infant population had a significantly higher mortality rate compared to other age groups (2% vs. 0.3%, <jats:italic>P<\/jats:italic> &lt; 0.001). Cerebral vascular accidents incurred the second highest median hospitalization cost ($18,956), behind ACS ($22,631). A high proportion of Caucasian patients died during hospitalization for VOC (0.4% vs. 0.1%, <jats:italic>P<\/jats:italic> = 0.014) and ACS (4% vs. 0.2%, <jats:italic>P<\/jats:italic> &lt; 0.001) when compared to non\u2010Caucasians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inpatient hospitalizations for secondary manifestations of pediatric SCD were associated with significant healthcare expenditures. Patients with an increased statistical risk for death during hospitalization included Caucasians with SCD complications of ACS and VOC, and patients &lt;1\u2010year\u2010old with ACS. Further research is needed to substantiate the associated clinical significance of these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26758","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T07:52:42Z","timestamp":1502524362000},"source":"Crossref","is-referenced-by-count":52,"title":["An analysis of inpatient pediatric sickle cell disease: Incidence, costs, and outcomes"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-1773","authenticated-orcid":false,"given":"Laura M.","family":"Bou\u2010Maroun","sequence":"first","affiliation":[{"name":"Central Michigan University, College of Medicine  Mt. Pleasant Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-6449","authenticated-orcid":false,"given":"Fabien","family":"Meta","sequence":"additional","affiliation":[{"name":"Department of Hematology Wayne State University School of Medicine  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis J.","family":"Hanba","sequence":"additional","affiliation":[{"name":"Department of Hematology Wayne State University School of Medicine  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Comprehensive Sickle Cell Program University of Michigan Medical Center  Ann Arbor Michigan"},{"name":"Division of Pediatric Hematology Oncology University of Michigan Medical Center  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Yanik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology University of Michigan Medical Center  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,12]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Pathophysiology of blood disorders","author":"Bunn HF","year":"2011"},{"key":"e_1_2_7_3_1","unstructured":"CDC.Sickle cell disease data & statistics.2016.http:\/\/www.cdc.gov\/ncbddd\/sicklecell\/data.html."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2011.607905"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2014.11.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.378"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"192","article-title":"Socioeconomic status and length of hospital stay in children with vaso\u2010occlusive crises of sickle cell disease","volume":"99","author":"Ellison AM","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20180"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510601046557"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11474"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.128"},{"key":"e_1_2_7_12_1","unstructured":"AHRQ.HCUP databases: KID overview.2016.https:\/\/www.hcup-us.ahrq.gov\/kidoverview.jsp."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.5.PEDS16137"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.10.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21840"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.12.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00145-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(97)00019-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2012.11.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08999.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1994.02170080026005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.10.765"},{"issue":"9","key":"e_1_2_7_23_1","first-page":"CD003425","article-title":"Splenectomy versus conservative management for acute sequestration crises in people with sickle cell disease","volume":"2015","author":"Owusu\u2010Ofori S","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta16430"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25563"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01041-7"},{"issue":"1","key":"e_1_2_7_27_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K","year":"1998","journal-title":"Blood"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsh065"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2015.1084315"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.93.10.1734"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12324"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22792"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:53:13Z","timestamp":1696035193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,12]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/pbc.26758"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26758","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,12]]},"article-number":"e26758"}}