{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:52:27Z","timestamp":1776217947004,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T00:00:00Z","timestamp":1503705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of a 14\u2010year\u2010old male with metastatic alveolar rhabdomyosarcoma, presenting with hypercalcaemia (3.89\u00a0mmol\/l) and elevated parathyroid hormone (PTH) level (10.2\u00a0pmol\/l). Imaging demonstrated extensive bony lytic damage, with \u201cfloating teeth\u201d in the mandible. Normalisation of calcium levels and bony reformation of the mandible occurred following chemotherapy; PTH levels decreased initially but remained above normal levels. Imaging did not demonstrate any evidence of parathyroid abnormality. Tumour ectopic PTH secretion is a very rare cause of hypercalcaemia of malignancy in children. Hypercalcaemia with an elevated PTH, in the absence of parathyroid\u2010related cause, should prompt investigation for underlying malignancy.<\/jats:p>","DOI":"10.1002\/pbc.26778","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T16:52:42Z","timestamp":1503766362000},"source":"Crossref","is-referenced-by-count":9,"title":["Hypercalcaemia secondary to ectopic parathyroid hormone expression in an adolescent with metastatic alveolar rhabdomyosarcoma"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-5120","authenticated-orcid":false,"given":"Rachael","family":"Brooks","sequence":"first","affiliation":[{"name":"Department of Paediatric Oncology University Hospital Southampton Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Lord","sequence":"additional","affiliation":[{"name":"Department of Paediatric Radiology University Hospital Southampton Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin H.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology University Hospital Southampton Foundation Trust  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet C.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology University Hospital Southampton Foundation Trust  Southampton UK"},{"name":"Cancer Sciences Unit University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"BurtME BrennanMF.Incidence of hypercalcemia and malignant neoplasm. Arch Surg.1980;115:704\u2013707.","DOI":"10.1001\/archsurg.1980.01380060012004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.04.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972883"},{"issue":"9","key":"e_1_2_6_5_1","first-page":"701","article-title":"Hypercalcemia and elevated serum parathyroid hormone level in association with rhabdomyosarcoma","volume":"108","author":"Elomaa I","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:1:083"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80152-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390050143029"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3616618"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.14.5048"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042806"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S51302"},{"key":"e_1_2_6_13_1","first-page":"912","article-title":"A thymoma as a cause of true ectopic hyperparathyroidism","volume":"79","author":"Rizzoli R","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199807000-00009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000151932.47598.00"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP14308.CR"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231907"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:55:27Z","timestamp":1696035327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,26]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/pbc.26778"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26778","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,26]]},"article-number":"e26778"}}