{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:55:27Z","timestamp":1785524127499,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to evaluate clinical characteristics, treatment, and survival of children, who were diagnosed with hepatoblastoma (HB) in their first 6 months of age, enrolled in the SIOPEL 2 and 3 protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010nine patients, treated between 1994 and 2006, were analyzed after stratification into three age groups:\u00a0&lt;1 month, between 1 and 3 months, and between 3 and 6 months. All received preoperative chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical characteristics were similar in both trials: 4 patients had pulmonary metastases at diagnosis, 4 had \u03b1\u2010fetoprotein\u00a0&lt;100\u00a0ng\/ml, 68 were operated by partial hepatectomy, and 7 received liver transplant. Chemotherapy courses were delayed in 8.5%, 8.4%, and 11.8% of cycles in the three groups. Doses were calculated according to weight for children\u00a0&lt;5 and 5\u201310\u00a0kg, and further reduced in 18.1%, 6.8%, and 5.9% of cycles. Acute toxicity was manageable. Long\u2010term hearing loss was the major problem at follow\u2010up occurring in two\u2010thirds of children. Ten patients experienced progression or relapse, and 5 of 10 died. After a median follow\u2010up of 5.6 years, the 5\u2010year overall survival (OS) and event\u2010free survival (EFS) were 91% (95% confidence interval [CI]: 84\u201396%) and 87% (95% CI: 78\u201392%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 5\u2010year OS and EFS of children\u00a0&lt;6 months of age affected by HB seem to be similar to those documented in the elder children. Dose reduction does not seem to jeopardize the long\u2010term outcome and may explain the lower toxicity profile. Ototoxicity though appears as high as in the whole population of SIOPEL 2 and 3. The treatment for these children should be further explored in international studies, particularly focusing on prevention of hearing loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26791","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:28:22Z","timestamp":1505744902000},"source":"Crossref","is-referenced-by-count":22,"title":["Hepatoblastoma in children aged less than six months at diagnosis: A report from the SIOPEL group"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-3272","authenticated-orcid":false,"given":"Patrizia","family":"Dall'Igna","sequence":"first","affiliation":[{"name":"Pediatric Surgery Division Department of Women's and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugieres","sequence":"additional","affiliation":[{"name":"Department of Oncology for Children and Adolescents Institute Gustave Roussy  Villejuif Cedez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sanlaville","family":"Christin","sequence":"additional","affiliation":[{"name":"Department of Oncology for Children and Adolescents Institute Gustave Roussy  Villejuif Cedez France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Maibach","sequence":"additional","affiliation":[{"name":"IBCSG Coordinating Center  Effingerstrasse 40 3008 Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casanova","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Pittsburgh of UPCM  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean de Ville","family":"de Goyet","sequence":"additional","affiliation":[{"name":"ISMETT \u2013 Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione Pediatric Surgery  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Zsiros","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Emma Children's Hospital Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Morland","sequence":"additional","affiliation":[{"name":"Department of Oncology Birmingham Children's Hospital  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Czauderna","sequence":"additional","affiliation":[{"name":"Department of Surgery and Urology for Children and Adolescents Medical University of Gdansk  Gdansk 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