{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:27:06Z","timestamp":1788211626590,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) are frequently diagnosed with vitamin D deficiency, which may impact outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>: To estimate the prevalence of vitamin D deficiency and examine its association with short\u2010term survival in pediatric HSCT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing HSCT at Phoenix Children's Hospital were retrospectively identified. Routine serum 25\u2010hydroxyvitamin D measurements were described prior to transplant and at 100 days and 1\u2010year post\u2010HSCT. Associations of pre\u2010HSCT vitamin D groups (i.e., normal \u226530\u00a0ng\/ml, insufficient 20\u201329\u00a0ng\/ml, and deficient\u00a0&lt;30\u00a0ng\/ml) with demographics, clinical factors, and outcomes were examined using nonparametric tests and Cox proportional hazards analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>: Among 72 study subjects, the median vitamin D pre\u2010HSCT was 26\u00a0ng\/ml (range: 19\u201334\u00a0ng\/ml). Levels were insufficient and deficient in 25 (35%) and 20 (28%) patients, respectively, with only two (3%) patients on supplemental therapy pre\u2010HSCT. Despite supplemental therapy provided to 46 (74%) subjects, insufficient\/deficient rates did not significantly change between pre\u2010HSCT and 100 days post\u2010HSCT, but mean vitamin D levels significantly increased by 1\u2010year post\u2010HSCT (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).Vitamin D pre\u2010HSCT was not associated with the development of acute or chronic graft\u2010versus\u2010host disease (GVHD) or delayed engraftment. Overall 1\u2010year survival was significantly lower for patients with deficient (65%) compared to normal (93%) pre\u2010HSCT vitamin D (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Suboptimal vitamin D levels are common in pediatric patients scheduled to receive HSCT and are associated with lower overall 1\u2010year survival. Further study is warranted to delineate the mechanisms underlying the role of vitamin D in successful HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26817","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:37:32Z","timestamp":1506613052000},"source":"Crossref","is-referenced-by-count":33,"title":["Vitamin D deficiency and outcomes in pediatric hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"65","author":[{"given":"Kristen","family":"Beebe","sequence":"first","affiliation":[{"name":"Center for Cancer and Blood Disorder Phoenix Children's Hospital  Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrie","family":"Magee","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorder Phoenix Children's Hospital  Phoenix 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