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The absence of human NF1 associated LGG\u2010derived cell lines, coupled with an inability to generate patient\u2010derived xenograft models, represents barriers to profile molecularly targeted therapies for these tumors. Thus, genetically engineered mouse models have been identified to evaluate the interplay between <jats:italic>Nf1<\/jats:italic>\u2010deficient tumor cells and nonneoplastic stromal cells to evaluate potential therapies for these neoplasms. 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