{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:07:19Z","timestamp":1769846839562,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Toronto, Department of Hematology"},{"name":"Alexandra Yeo scholarship, Alexandra Yeo Student Research Program 2016"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood transfusions and fractionated products are not without risk and may lead to acute and long\u2010term adverse events. The objective of this study was to evaluate the appropriateness of usage of frozen plasma (FP), cryoprecipitate (CRYO), and recombinant factor VIIa (rVIIa) in a pediatric setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All orders for FP, CRYO, and rVIIa were prospectively audited over 6\u00a0weeks. Data collected included demographics, laboratory values, indication, and adverse reactions. The appropriateness of each order was independently evaluated using adjudication criteria rated by two hematologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred sixty\u2010five products were ordered; 67% of the orders were issued to operating rooms or intensive care units. The most common indication for all products was cardiac surgery. FP was ordered as fluid replacement (15\/215; 7%) to correct abnormal coagulation tests (23\/215; 11%) and for patients with minor or no bleeding (111\/242; 46%). FP was more likely to alter the international normalized ratio (INR) if the INR was over 2.0 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The rate of inappropriate products was judged as FP 19%, CRYO 21%, and rVIIa 91%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FP, CRYO, and rVIIa are most commonly used in the operating room and intensive care units. FP was often used for fluid resuscitation and for patients with mild to no bleeding. FP was only effective in lowering the INR when the INR was over 2.0. Use of rVIIa was rarely ordered for an appropriate indication. Results of this study inform its readers where trials of pediatric transfusion should be performed to clarify how these products should be used in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26933","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T15:12:58Z","timestamp":1514560378000},"source":"Crossref","is-referenced-by-count":8,"title":["Utilization of frozen plasma, cryoprecipitate, and recombinant factor VIIa for children with hemostatic impairments: An audit of transfusion appropriateness"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3633-0728","authenticated-orcid":false,"given":"Lani","family":"Lieberman","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Clinical Pathology Sunnybrook Health Sciences Center  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi Long","family":"Yi","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Pendergrast","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Callum","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Clinical Pathology Sunnybrook Health Sciences Center  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"From the QUEST\u2014Quality in Utilization Education and Safety in Transfusion\u2014Research Collaborative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.019760"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12095"},{"key":"e_1_2_13_4_1","unstructured":"Royal College of Pathologists.Serious hazards of transfusion. 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