{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:42:26Z","timestamp":1782747746847,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Efficacy and role of cytoreductive surgery (CRS) and hyperthermic peritoneal perfusion with chemotherapy (HIPEC) remain poorly documented in pediatric tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective national study analyzed all pediatric patients with peritoneal tumor spread treated by CRS and HIPEC as part of a multimodal therapy in France from 2001 to 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients (nine males and 13 females) were selected. The median age at diagnosis was 14.8 years (4.2\u201317.6). Seven had peritoneal mesotheliomas; seven, desmoplastic small round cells tumors (DSRCT); and eight, other histologic types. A complete macroscopic resection (CC\u20100, where CC is completeness of cytoreduction) was achieved in 16 (73%) cases. Incomplete resections were classified as CC\u20101 in four (18%) cases and CC\u20102 in two (9%) cases. Fourteen (64%) patients had complications within 30 days from HIPEC, requiring an urgent laparotomy in eight (36%) cases. Thirteen (59%) patients received adjuvant chemotherapy and four (18%) received total abdominal radiotherapy after surgery. Sixteen (72%) patients had relapse after a median time of 9.6 months (1.4\u201386.4) and nine (41%) eventually died after a median time of 5.3 months (0.1\u201336.1) from relapse. Six (27%) patients (four mesotheliomas, one pseudopapillary pancreatic tumor, and one DSRCT) were alive and in complete remission after a median follow\u2010up of 25.0 months (5.3\u201378.2).<\/jats:p><jats:p>The mean overall survival (OS) and disease\u2010free survival (DFS) were 57.5 months (95% CI [38.59\u201376.32]) and 30.9 months (95% CI [14.96\u201346.77]). Patients with a peritoneal mesothelioma had a significantly better OS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015) and DFS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) than other histologic type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this national series, outcomes of HIPEC are encouraging for the treatment of peritoneal mesothelioma in children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26934","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T15:12:56Z","timestamp":1514560376000},"source":"Crossref","is-referenced-by-count":22,"title":["Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread: A French nationwide study over 14 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