{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:56:14Z","timestamp":1792565774701,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pearson syndrome (PS) is a rare mitochondrial disorder that usually presents with transfusion\u2010dependent macrocytic anemia, exocrine pancreatic dysfunction, and lactic acidosis. Typical bone marrow (BM) features are vacuolization in hematopoietic progenitors, hypocellularity, and ringed sideroblasts. At the neonatal age, PS may have a variable clinical onset. Moreover, there is little information about BM features at this age and the timing of their presentation. We report a neonatal case of PS that presented with refractory anemia and atypical BM features. We reviewed the BM findings in neonatal\u2010onset PS cases to stress the importance and limitations of BM evaluation at this age.<\/jats:p>","DOI":"10.1002\/pbc.26939","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T15:06:38Z","timestamp":1514559998000},"source":"Crossref","is-referenced-by-count":20,"title":["Bone marrow features in Pearson syndrome with neonatal onset: A case report and review of the literature"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0366-7348","authenticated-orcid":false,"given":"Elisa","family":"Tadiotto","sequence":"first","affiliation":[{"name":"Pediatric Clinic Department of Life and Reproduction Sciences Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Maines","sequence":"additional","affiliation":[{"name":"Pediatric Unit Provincial Centre for Rare Diseases Department of Maternal and Child Health Azienda Provinciale per i Servizi Sanitari  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Degani","sequence":"additional","affiliation":[{"name":"Pediatric Clinic Department of Life and Reproduction Sciences Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Balter","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Unit Department of Pediatrics Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bordugo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regional Centre for Newborn Screening Diagnosis and Treatment of Inherited Metabolic Diseases and Congenital Endocrine Diseases Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-9547","authenticated-orcid":false,"given":"Simone","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Unit Department of Pediatrics Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80286-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2015_470"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181bbc4ef"},{"key":"e_1_2_9_5_1","first-page":"2492","article-title":"A novel mitochondrial DNA deletion in a patient with Pearson syndrome and neonatal diabetes mellitus provides insight into disease etiology, severity and progression","volume":"27","author":"Chen XY","year":"2016","journal-title":"Mitochondrial DNA A DNA Mapp Seq Anal"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199908000-00023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005378527077"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2006.12.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34288"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80470-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2009.10.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010122)98:3<205::AID-AJMG1077>3.0.CO;2-P"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005305422544"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05178.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9778-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(92)90005-Q"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9440-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.10.737"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.12.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571687"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-008-0756-4"}],"container-title":["Pediatric Blood &amp; 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