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All three episodes occurred during or just after the induction or reinduction phase of treatment based on prednisone\/dexamethasone, vincristine, daunorubicin, and pegylated\u2010<jats:sc>l<\/jats:sc>\u2010asparaginase. SOS episodes were categorized as mild\/moderate and resolved in 7, 10, and 16 days using supportive measures or defibrotide therapy. In all three episodes, the clinical diagnosis of SOS was associated with a significant increase in plasminogen\u2010activator inhibitor\u20101 (PAI\u20101) that reduced with patient clinical improvement. PAI\u20101 warrants study as a diagnostic marker for SOS in ALL.<\/jats:p>","DOI":"10.1002\/pbc.26963","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T11:15:00Z","timestamp":1516360500000},"source":"Crossref","is-referenced-by-count":8,"title":["Venoocclusive disease due to chemotherapy for pediatric acute lymphoblastic leukemia is associated with increased levels of plasminogen\u2010activator inhibitor\u20101"],"prefix":"10.1002","volume":"65","author":[{"given":"Margherita","family":"Mauro","sequence":"first","affiliation":[{"name":"Pediatric Hematology Oncology Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Saggiorato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Medicine I, University of Padova  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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