{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:42:45Z","timestamp":1784562165037,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Pericardial effusion (PE) is a potentially life\u2010threatening complication following hematopoietic stem cell transplantation (HCT). A higher incidence of early\u2010onset PE, unrelated to graft\u2010versus\u2010host disease, before day 100 after HCT has been reported in pediatric patients, but the pathogenic mechanism is poorly understood. Aiming to determine the pathogenesis of early\u2010onset PE in pediatric patients, we analyzed the cytokine concentration and cell population in the pericardial fluid of four pediatric patients with PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2009 and December 2015, four patients requiring pericardiocentesis for clinically significant PE were identified in 60 patients. We evaluated the interleukin\u20106 (IL\u20106), interferon\u2010\u03b3, IL\u20101\u03b2, and tumor necrosis factor\u2010\u03b1 levels in PE. Two patients were available for analysis with intracellular cytokine flow cytometry and a chimerism assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients showed the accumulation of pericardial macrophages and high concentrations of IL\u20106 in PE. Notably, the accumulated pericardial macrophages were CD163<jats:sup>+<\/jats:sup>CD15<jats:sup>+<\/jats:sup>CD14<jats:sup>+<\/jats:sup> cells of host origin that produced IL\u20106.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These IL\u20106\u2010producing tissue\u2010resident macrophages may be key players in the pathogenesis of early\u2010onset PE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26982","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:54:32Z","timestamp":1517424872000},"source":"Crossref","is-referenced-by-count":5,"title":["Possible involvement of IL\u20106\u2010producing tissue\u2010resident macrophages in early\u2010onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-0366","authenticated-orcid":false,"given":"Satoru","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokiko","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Kiyuna","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Okinawa Prefectural Nanbu Medical Center Children's Medical Center  Arakawa Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Okinawa Prefectural Nanbu Medical Center Children's Medical Center  Arakawa Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Higa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Okinawa Prefectural Nanbu Medical Center Children's Medical Center  Arakawa Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Hyakuna","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine University of Ryukyus  Nishihara Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.227"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13357"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.149"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12062"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705626"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.38.6.709"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081633"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.11.026"},{"key":"e_1_2_8_11_1","article-title":"Incidence and outcome of pericardial effusion in pediatric patients after hematopoietic stem cell transplant: a single\u2010institution experience","author":"Diamond M","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"710","article-title":"IL\u20106 increases endothelial permeability in vitro","volume":"131","author":"Maruo N","year":"1992","journal-title":"Endocrinology"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24435"},{"issue":"5","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.18632\/aging.100669","article-title":"Age\u2010related changes in tissue macrophages precede cardiac functional impairment","volume":"6","author":"Pinto AR","year":"2014","journal-title":"Aging"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71017-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2012-007834","article-title":"Successful treatment of massive intractable pericardial effusion in a patient with systemic lupus erythematosus with tocilizumab","volume":"2012","author":"Kamata Y","year":"2012","journal-title":"BMJ Case Rep"},{"issue":"3","key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/s10165-010-0377-4","article-title":"A case of rheumatoid pericarditis associated with a high IL\u20106 titer in the pericardial fluid and tocilizumab treatment","volume":"21","author":"Ozaki Y","year":"2011","journal-title":"Mod Rheumatol"},{"issue":"19","key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1053\/euhj.2002.3152","article-title":"Intrapericardial treatment of autoreactive pericardial effusion with triamcinolone; the way to avoid side effects of systemic corticosteroid therapy","volume":"23","author":"Maisch B","year":"2002","journal-title":"Eur Heart J"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:12:34Z","timestamp":1695543154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/pbc.26982"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26982","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]},"article-number":"e26982"}}