{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:16:12Z","timestamp":1790266572057,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Compared to younger and older age groups, the incidence of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) has increased more in the adolescent and young adult (AYA) population, the cause of which is unknown. As of the last decade, only half of the AYA patients with these diseases were surviving 10 years. Strong evidence exists that favors \u201cpediatric\u201d treatment regimens for AYAs compared to \u201cadult\u201d treatment regimens in terms of survival rates, hospitalization time, toxicities, late effects, and quality of life both during and after treatment. Targeted agents are clinically accessible for certain subsets of patients with Philadelphia\u2010like ALL, the incidence of which peaks in AYAs. Treatment teams must appreciate the complex psychosocial underpinnings in these patients in order to maximize compliance with the prolonged and complex treatment plans during the AYA years.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#pbc26989-bib-0001\"\/><\/jats:p>","DOI":"10.1002\/pbc.26989","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T11:22:37Z","timestamp":1518088957000},"source":"Crossref","is-referenced-by-count":40,"title":["Acute lymphoblastic leukemia and lymphoblastic lymphoma in adolescents and young adults"],"prefix":"10.1002","volume":"65","author":[{"given":"Jennifer L.","family":"McNeer","sequence":"first","affiliation":[{"name":"Section of Pediatric Hematology\/Oncology\/Stem Cell Transplant Department of Pediatrics University of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-5146","authenticated-orcid":false,"given":"Archie","family":"Bleyer","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Oregon Health &amp; Science University  Bend Oregon"},{"name":"Department of Pediatrics University of Texas Medical School at Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-33679-4_7"},{"key":"e_1_2_11_3_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat Database: Incidence\u2014SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases Nov 2015 Sub (1973\u20102013 varying) \u2014Linked To County Attributes\u2014Total U.S. 1969\u20132014 Counties National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released April 2016 based on the November 2015 submission. SEER*Stat software.2017.https:\/\/seer.cancer.gov\/seerstat\/"},{"key":"e_1_2_11_4_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat database: incidence\u2014SEER 13 Regs Research Data Nov 2015 Sub (1992\u20102013) <Katrina\/Rita Population Adjustment>\u2010 Linked To County Attributes\u2014Total U.S. 1969\u20132014 Counties National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released April 2016 based on the November 2015 submission. SEER*Stat software.2017.https:\/\/seer.cancer.gov\/seerstat\/."},{"key":"e_1_2_11_5_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat Database: incidence\u2014SEER 9 Regs Research Data Nov 2015 Sub (1973\u20132013) <Katrina\/Rita Population Adjustment>\u2010 Linked To County Attributes\u2014Total U.S. 1969\u20132014 Counties National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released April 2016 based on the November 2015 submission. SEER*Stat software.2017.https:\/\/seer.cancer.gov\/seerstat\/."},{"key":"e_1_2_11_6_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat database: mortality\u2014all COD Aggregated With State Total U.S. (1969\u20132014) <Katrina\/Rita Population Adjustment> National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released December 2016. Underlying mortality data provided by NCHS (www.cdc.gov\/nchs). SEER*Stat software.2017.https:\/\/seer.cancer.gov\/seerstat\/."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12112"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.7792"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1182\/blood.V124.21.556.556","article-title":"Impact of care at NCI Comprehensive Cancer Centers on outcomes in children, adolescents and young adults with hematologic malignancies","volume":"124","author":"Wolfson J","year":"2014","journal-title":"Blood"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"issue":"6","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-2005-872515","article-title":"Prognostic impact of age in children and adolescents with acute lymphoblastic leukemia: data from the trials ALL\u2010BFM","volume":"86","author":"M\u00f6ricke A","year":"2005","journal-title":"Klin Padiatr"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401965"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.262"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.261"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.257"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.253"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.6364"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.8.2025.bloodjournal8582025"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27617"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07417.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr094"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.317"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.1308"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2958"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-261586"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.30"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808253"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70339-5"},{"issue":"15","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1182\/blood-2012-10-462358","article-title":"Independent prognostic value of BCR\u2010ABL1\u2010like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B\u2010cell precursor ALL","volume":"122","author":"der Veer A","year":"2013","journal-title":"Blood"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403088"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1412123"},{"issue":"10","key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1158\/1078-0432.CCR-11-1936","article-title":"Advances in the genetics of high\u2010risk childhood B\u2010progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy","volume":"18","author":"Loh ML","year":"2012","journal-title":"Clin Cancer Res"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208397"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.469"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245944"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.06.005"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.252"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.250"},{"issue":"4","key":"e_1_2_11_39_1","first-page":"195","article-title":"Acute lymphoblastic leukemia therapy study BFM 79\/81 in children and adolescents: intensified reinduction therapy for patients with different risk for relapse","volume":"194","author":"Henze G","year":"1982","journal-title":"Klin Padiatr"},{"issue":"3","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1200\/JCO.1993.11.3.527","article-title":"Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial","volume":"11","author":"Tubergen DG","year":"1993","journal-title":"J Clin Oncol"},{"issue":"2","key":"e_1_2_11_41_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1200\/JCO.1994.12.2.273","article-title":"Blasts in CSF with a normal cell count do not justify alteration of therapy for acute lymphoblastic leukemia in remission: a Childrens Cancer Group study","volume":"12","author":"Tubergen DG","year":"1994","journal-title":"J Clin Oncol"},{"issue":"2","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1200\/JCO.2003.04.096","article-title":"Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture","volume":"21","author":"B\u00fcrge B1","year":"2003","journal-title":"J Clin Oncol"},{"issue":"15","key":"e_1_2_11_43_1","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1200\/JCO.2005.03.9727","article-title":"Prognostic significance of blasts in the cerebrospinal fluid without pleiocytosis or a traumatic lumbar puncture in children with acute lymphoblastic leukemia: experience of the Dutch Childhood Oncology Group","volume":"24","author":"Loo DM","year":"2006","journal-title":"J Clin Oncol"},{"issue":"2","key":"e_1_2_11_44_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejca.2010.10.019","article-title":"Prognostic significance of the initial cerebro\u2010spinal fluid (CSF) involvement of children with acute lymphoblastic leukaemia (ALL) treated without cranial irradiation: results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group study 58881","volume":"47","author":"Sirven N1","year":"2011","journal-title":"Eur J Cancer"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845415Y.0000000020"},{"issue":"3","key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1200\/JCO.1989.7.3.316","article-title":"Three versus five years of maintenance therapy are equivalent in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group","volume":"7","author":"Miller DR","year":"1989","journal-title":"J Clin Oncol"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.6397"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e3181ff6509"},{"key":"e_1_2_11_49_1","unstructured":"Acute Lymphoblastic Leukemia National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology.2017.https:\/\/www.nccn.org\/store\/login\/login.aspx?ReturnURL=https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/all.pdf."},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2014.12.006"},{"key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood.V124.21.796.796","article-title":"Favorable Outcomes for Older Adolescents and Young Adults (AYA) with Acute Lymphoblastic Leukemia (ALL): early Results of U.S. Intergroup Trial C10403","volume":"124","author":"Stock W","year":"2014","journal-title":"Blood"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.229"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28930"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.547"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20668"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-045351"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116582"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.116"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-130237"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.053"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403538"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22189"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20749"},{"issue":"8","key":"e_1_2_11_64_1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3324\/haematol.12466","article-title":"Acute lymphoblastic leukemia in adolescents and young adults in Finland","volume":"93","author":"Usvasalo A","year":"2008","journal-title":"Haematologica"},{"issue":"4","key":"e_1_2_11_65_1","first-page":"578","article-title":"Prognosis of ALL in 10\u201020 year old patients in Denmark 1999\u20102001","volume":"45","author":"Schroeder H","year":"2005","journal-title":"Pediat Blood Cancer"},{"key":"e_1_2_11_66_1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1182\/blood.V104.11.1954.1954","article-title":"Difference in outcome of adolescents with acute lymphoblastic leukemia (ALL) enrolled in pediatric (AIEOP) and adult (GIMEMA) protocols","volume":"104","author":"Testi AM","year":"2004","journal-title":"Blood"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.72"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.529202"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375258"},{"key":"e_1_2_11_70_1","first-page":"179","article-title":"Hyper\u2010CVAD compared with BFM\u2010like chemotherapy for the treatment of adult acute lymphoblastic leukemia. A retrospective single\u2010center analysis","author":"El\u2010Cheikh J","year":"2016","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24419"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1211"},{"key":"e_1_2_11_73_1","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1182\/blood.V122.21.3903.3903","article-title":"Frontline\u2010treatment of acute lymphoblastic leukemia in older adolescents and young adults using a pediatric regimen is feasible: toxicity results of the prospective U.S. Intergroup Trial C10403 (Alliance)","volume":"122","author":"Advani AS","year":"2013","journal-title":"Blood"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445098"},{"key":"e_1_2_11_75_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V124.21.319.319","article-title":"Superiority of pediatric chemotherapy over allogeneic hematopoietic cell transplantation for Philadelphia chromosome negative adult ALL in first complete remission: a combined analysis of Dana\u2010Farber ALL Consortium and CIBMTR Cohorts","volume":"124","author":"Seftel MD","year":"2014","journal-title":"Blood"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-599894"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.596963"},{"key":"e_1_2_11_78_1","doi-asserted-by":"crossref","first-page":"LBA2","DOI":"10.1200\/jco.2015.33.18_suppl.lba2","article-title":"Reduction in late mortality among 5\u2010year survivors of childhood cancer: a report from the Childhood Cancer Survivor Study","volume":"33","author":"Armstrong GT","year":"2015","journal-title":"J Clin Oncol"},{"key":"e_1_2_11_79_1","first-page":"47","article-title":"Applying pediatric therapeutic strategies to adults with acute lymphoblastic leukemia and lymphoma. II. Comparison with adult treatment regimens, including hyper\u2010CVAD","volume":"2014","author":"Douer D","journal-title":"Am Oncol Hemat Rev"},{"key":"e_1_2_11_80_1","unstructured":"National Comprehensive Cancer Network.Adolescent and Young Adult (AYA) Oncology National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. 2014."},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2016.0049"},{"key":"e_1_2_11_82_1","article-title":"QoL of pediatric\u2010inspired compared to hyper\u2010CVAD regimens for newly diagnosed AYA patients with Ph\u2010ALL: a modeling analysis. 2017 American Society of Clinical Oncology Annual Meeting","volume":"35","author":"Hooper E","year":"2017","journal-title":"J Clin Oncol"},{"issue":"21","key":"e_1_2_11_83_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1182\/blood.V122.21.771.771","article-title":"Suffering before the cure: evaluation of psychological morbidities in adolescents and young adults with hematologic malignancies in early survivorship","volume":"122","author":"Muffly LS","year":"2013","journal-title":"Blood"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.2802"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-552166"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.303"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.7466"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:13:41Z","timestamp":1695543221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/pbc.26989"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26989","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]},"article-number":"e26989"}}