{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:23:18Z","timestamp":1780604598551,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NCI Cancer Center","award":["P30 CA091842"],"award-info":[{"award-number":["P30 CA091842"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sensorineural hearing loss due to ototoxic cancer therapy is well established; effects on the vestibular system are unknown. We examined the feasibility of implementing vestibular screens for pediatric cancer survivors exposed to ototoxic agents. The prevalence of screening failures is reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cancer survivors who were 6\u201317 years, at least 1\u2010month posttreatment, and received ototoxic therapy (radiation to the head\/neck, cisplatin, carboplatin) were eligible. Screening measures included (1) Pediatric Vestibular Symptom Questionnaire, (2) Modified Clinical Test of Sensory Interaction on Balance, and (3) Dynamic Visual Acuity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vestibular screening failures were observed in 30 participants (60%). Patients with a brain tumor diagnosis were at increased risk for failures compared to nonbrain tumor patients (74.2%\u00a0vs. 36.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). Patients who underwent brain surgery were at increased risk for failures compared to patients without brain surgery (71%\u00a0vs. 42%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). Patients with a longer duration between end of treatment and vestibular screening had a reduced risk of failures, with an almost 20% decrease for each year between the time points (odds ratio\u00a0=\u00a00.812; 95% confidence interval: 0.683\u20130.964, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018). Receiving carboplatin correlated with a decreased risk of failure (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016), due to a negative correlation with other clinical risk factors (diagnosis of a brain tumor, major brain surgery) that are associated with vestibular screening failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vestibular screening failures are highly prevalent in childhood cancer survivors who received ototoxic therapy. Broad screening of this population and further characterization of these patients are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26992","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T09:04:04Z","timestamp":1517303044000},"source":"Crossref","is-referenced-by-count":14,"title":["Determining the prevalence of vestibular screening failures in pediatric cancer patients whose therapies include radiation to the head\/neck and platin\u2010based therapies: A pilot study"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-7112","authenticated-orcid":false,"given":"Miranda L.","family":"Camet","sequence":"first","affiliation":[{"name":"Program in Audiology and Communication Sciences Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Audiology St. Louis Children's Hospital  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda C.","family":"Sinks","sequence":"additional","affiliation":[{"name":"Dizziness and Balance Center, Department of Otolaryngology Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Gettinger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology St. Louis Children's Hospital  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Hite","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University School of Medicine  St. Louis 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University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Department of Pediatrics, Washington University School of Medicine  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_9_3_1","first-page":"61","article-title":"Survivors of childhood and adolescent cancer: life\u2010long risks and responsibilities","volume":"14","author":"Robinson 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