{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:51:39Z","timestamp":1785426699951,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2011M27"],"award-info":[{"award-number":["YG2011M27"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["YG2015MS36"],"award-info":[{"award-number":["YG2015MS36"]}],"id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatoblastoma (HB) is the most common liver cancer found in early childhood. These patients suffer poor outcomes and need novel therapies. An abnormal activation of Wnt signaling is the hallmark of HB tumorigenesis, and its pathway is a potential candidate for a pharmacological intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Tissue samples of patients with HB were collected for RNA\u2010seq, quantitative real\u2010time PCR, and immunohistochemistry to identify if disheveled\u20102 (Dvl\u20102) was a target gene. The correlation between Dvl\u20102 expression and different clinicopathological features was analyzed using statistical methods. Proliferation and invasion assays were applied after knocking down Dvl\u20102 by shRNA in HepG2 and Huh6 HB cell lines. The antitumor effect of niclosamide on HB was ascertained in vitro and in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dvl\u20102 was overexpressed in 90% of patients with HB, and Dvl\u20102 expression was positively correlated with the age of patients with HB. Knockdown of Dvl\u20102 could inhibit proliferation and invasion of HB cell lines. Also, niclosamide, a Food and Drug Administration approved antihelminth compound, could effectively inhibit HB cell growth in vitro and in vivo via downregulation of Dvl\u20102 and \u03b2\u2010catenin expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results implicate that Dvl\u20102 is a potential therapeutic target in HB, and niclosamide could have clinical potential to treat patients with HB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27032","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T10:48:40Z","timestamp":1520851720000},"source":"Crossref","is-referenced-by-count":12,"title":["Down\u2010regulation of dishevelled\u20102 inhibits cell proliferation and invasion in hepatoblastoma"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4272-5670","authenticated-orcid":false,"given":"Siqi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Surgery 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