{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:00:47Z","timestamp":1780920047357,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["109714"],"award-info":[{"award-number":["109714"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pediatric fibrotic myelodysplastic syndromes (ped\u2010MDS\u2010MF) and pediatric primary myelofibrosis (ped\u2010PMF) are rare, and the molecular changes which mediate fibrosis have never been investigated. Histology and gene expression profile of 119 fibrosis\/angiogenesis\/inflammation\/megakaryopoiesis\u2010related factors in bone marrow biopsies were performed (two ped\u2010MDS\u2010MF and one ped\u2010PMF). In one progressive ped\u2010MDS, comparison of MF grade 0 (no myelofibrosis) and MF grade 2 (dense network of reticulin fibres) after 4 months showed that expression of fibrosis\u2010related transcripts increased and dysplastic megakaryocytes formed a dense net of CD42b<jats:sup>+<\/jats:sup> proplatelets. These changes were not observed in another ped\u2010MDS\u2010MF, whereas ped\u2010PMF showed a similar proplatelet pattern. These findings indicate that fibrotic changes in ped\u2010MDS may involve proplatelet\u2010related and unrelated pathways.<\/jats:p>","DOI":"10.1002\/pbc.27048","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T11:01:48Z","timestamp":1524049308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular profile of inflammatory and megakaryocytic factors in pediatric myelodysplastic syndrome with acute myelofibrosis"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-1565","authenticated-orcid":false,"given":"Kais","family":"Hussein","sequence":"first","affiliation":[{"name":"Institute of Pathology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinolf","family":"Suttorp","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University Hospital Carl Gustav Carus Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Stucki\u2010Koch","sequence":"additional","affiliation":[{"name":"Institute of Pathology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irith","family":"Baumann","sequence":"additional","affiliation":[{"name":"Institute of Pathology Health Center B\u00f6blingen  B\u00f6blingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte M.","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology Medical Center \u2013 University of Freiburg Faculty of Medicine, University of Freiburg  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kreipe","sequence":"additional","affiliation":[{"name":"Institute of Pathology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"387","article-title":"Hematopoietic disorders in Down syndrome","volume":"1","author":"Choi JK","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402765"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-015-0256-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12871"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/670580"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.73"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.03.040"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1024-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.07.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/351089"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2054"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:53:29Z","timestamp":1695513209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,18]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/pbc.27048"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27048","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,18]]},"assertion":[{"value":"2017-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27048"}}