{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:03:45Z","timestamp":1753869825243,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Ministry of Health, Labour and Welfare of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently, there is no standardized treatment for adolescents, aged 15 years or older, with mature B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL), although this age group has been reported to have a poorer prognosis than younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The present study analyzed the data of 321 patients with B\u2010NHL, enrolled in a pediatric clinical trial, comparing the treatment outcomes between adolescents (aged 15\u201318 years, <jats:italic>n<\/jats:italic>\u00a0=\u00a025) and children (\u226415 years, <jats:italic>n<\/jats:italic>\u00a0=\u00a0297), with a particular focus on the safety and tolerability of administering pediatric regimens to adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The probability of event\u2010free survival (EFS) at 4 years was 79.3 \u00b1 8.3% for the adolescents and 88.0 \u00b1 1.9% for the children (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.236). After adjusting for treatment group and lactate dehydrogenase value at the time of diagnosis, the probability of 4\u2010year EFS of adolescents was lower than that of children, but only in the patients with central nervous system positive lymphoma or Burkitt leukemia. The frequency of treatment\u2010related mortalities, severe adverse events (SAEs), and SAEs leading to treatment discontinuation or treatment completion rate was similar in adolescent and pediatric patients. There was no difference in treatment duration between adolescent and pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The treatment outcomes of adolescents with B\u2010NHL were not statistically different from those of the pediatric patients and the safety of a pediatric regimen in adolescents was similar to that in the pediatric patients. A pediatric treatment foundation can be adopted for adolescents, although further prospective studies and biological investigations are required for treatment optimization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27068","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:56:23Z","timestamp":1523408183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of administering pediatric treatment to adolescent patients with mature B\u2010cell non\u2010Hodgkin lymphoma within the Japanese Pediatric Leukemia\/Lymphoma Study Group clinical trial"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-2673","authenticated-orcid":false,"given":"Masahiro","family":"Sekimizu","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nagoya Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Nagoya Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Marianna University  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-0856","authenticated-orcid":false,"given":"Ryoji","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology for Children and Adolescents Sapporo Hokuyu Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Horibe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nagoya Medical Center  Aichi Japan"},{"name":"Clinical Research Center National Hospital Organization Nagoya Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Tsurusawa","sequence":"additional","affiliation":[{"name":"Advanced Medical Research Center Aichi Medical University  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.053"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403538"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22189"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20749"},{"key":"e_1_2_8_6_1","first-page":"76","article-title":"Acute lymphoblastic leukemia in adolescents between 10 and 19 years of age in Denmark\u2010secondary publication","volume":"53","author":"Schroder H","year":"2006","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24975"},{"volume-title":"WHO Classification of Tumors, Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues","year":"2001","author":"Jaffe ES","key":"e_1_2_8_8_1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04134.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.3369"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.245"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27659"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28342"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.30.18_suppl.cra9508"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23149"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70235-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61040-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70481-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60313-X"}],"container-title":["Pediatric Blood &amp; 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