{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:53:39Z","timestamp":1789538019720,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study's aim was to review the literature regarding past and current practices in managing incidental appendiceal carcinoid tumors and need for more procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A search of MEDLINE, Embase, CINAHL, and Cochrane databases of systematic reviews was undertaken of the English language literature. The mesh terms used were \u201ccarcinoid\u201d or \u201cneuroendocrine,\u201d \u201ctumour\u201d or \u201ctumor,\u201d \u201cappendix,\u201d \u201cappendicectomy,\u201d or \u201cappendectomy,\u201d and \u201cchild,\u201d \u201cpediatric,\u201d or \u201cpaediatric.\u201d Of the 369 articles found, 37 met the inclusion criteria. Our hospital records and pathology database identified 11 patients with confirmed histological diagnosis of appendicular carcinoids from January 1996 to December 2016. Those cases were also included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 958 cases were identified from the literature and our own experience. There were 566 females and 343 males giving us a ratio of 1.65:1. The frequency was 0.3% of appendicectomies. There was a 28\u2010fold increase in the risk of having a positive lymph node if the tumor size was\u00a0&gt;2\u00a0cm compared with the risk of having a positive lymph node if the tumor size was \u22642\u00a0cm. There was no recurrence or mortality for those with criteria for secondary surgery, who were observed after appendicectomy compared to those that had secondary surgery. Mean follow\u2010up was 58.6 months (4.8 years) with a range of 0\u2013396 months (33 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Appendicectomy alone is an adequate treatment for an appendicular carcinoid in children irrespective of size, position, lymph node, or mesenteric involvement. Post\u2010appendicectomy investigations were found to be not helpful in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27069","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T07:27:14Z","timestamp":1525937234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Systematic review and meta\u2010analysis of appendiceal carcinoid tumors in children"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-1373","authenticated-orcid":false,"given":"Ike","family":"Njere","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Linn\u00e9a","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery St George's University Hospitals NHS Foundation Trust  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