{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:15:01Z","timestamp":1780758901306,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fund for Ophthalmic Knowledge"},{"name":"Cure2children Foundation"},{"name":"Fundacion Natali Dafne Flexer"},{"name":"Fundacion Leo Messi"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The feasibility and results of intraarterial chemotherapy, also termed ophthalmic artery chemosurgery (OAC), for retinoblastoma in less developed countries have seldom been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A retrospective evaluation of a program of OAC in Argentina from 2010 to 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010seven eyes from 81 patients (61 bilateral) were analyzed. In 35 eyes, OAC was given as primary therapy and in 62 it was used for the treatment of tumors with partial response or those relapsing after systemic chemoreduction with focal therapy or external\u2010beam radiotherapy. Twenty\u2010two primarily treated eyes had group D and 13 groups B\/C. A total of 400 procedures were carried out. Chemotherapy used included combinations of melphalan, carboplatin, and topotecan. There was no mortality associated with OAC. Toxicity included fever and neutropenia in five (1.25%), hypotension and bradycardia during anesthesia in two and femoral thrombosis in one, eyelid edema in nine, and neutropenia or thrombocytopenia in 28 cycles. With a median follow\u2010up of 48.7 months (range 12\u201379), the 3\u2010year probability of event\u2010free survival (pEFS) (enucleation and\/or radiotherapy were considered events) was comparable for patients who received first\u2010line therapy and those treated at relapse (0.65 vs. 0.63, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.5). In the former, the pEFS was 0.91 and 0.43 for groups B\/C and D, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Two patients died of extraocular dissemination after refusal of enucleation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OAC was feasible with low toxicity. pEFS improved in all groups compared to the previous experience with systemic chemotherapy reducing the use of radiotherapy. The overall mortality associated with OAC is comparable to our previous experience with systemic chemoreduction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27086","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T12:25:19Z","timestamp":1524659119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Feasibility and results of an intraarterial chemotherapy program for the conservative treatment of retinoblastoma in Argentina"],"prefix":"10.1002","volume":"65","author":[{"given":"Santiago","family":"Funes","sequence":"first","affiliation":[{"name":"Pediatric Hemato\u2010Oncology Service Hospital Universitario Austral  Pilar Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sampor","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology Service Hospital JP Garrahan  Buenos Aires 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