{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:08:03Z","timestamp":1790744883225,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial adenomatous polyposis (FAP) due to <jats:italic>APC<\/jats:italic> mutation is associated with an increased risk of hepatoblastoma. All cases of hepatoblastoma in patients with FAP reported in the literature were reviewed. One hundred and nine patients were identified. Thirty\u2010five patients (of 49 with data) were diagnosed with hepatoblastoma prior to a later diagnosis of FAP (often in association with advanced colorectal carcinoma), emphasizing a need to identify patients earlier with germline <jats:italic>APC<\/jats:italic> mutations for early colorectal carcinoma screening. Hepatoblastoma may present at birth, and screening for hepatoblastoma in infancy in families with FAP prior to <jats:italic>APC<\/jats:italic> mutation testing results may be warranted.<\/jats:p>","DOI":"10.1002\/pbc.27103","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T17:30:53Z","timestamp":1525282253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Hepatoblastoma in patients with molecularly proven familial adenomatous polyposis: Clinical characteristics and rationale for surveillance screening"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-7686","authenticated-orcid":false,"given":"Angela D.","family":"Trobaugh\u2010Lotrario","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology Sacred Heart Children's Hospital  Spokane WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"L\u00f3pez\u2010Terrada","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Children's Hospital and Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Texas Children's Hospital and Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Feusner","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital &amp; Research Center Oakland  Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000129"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20122"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0432"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.019"},{"key":"e_1_2_7_6_1","first-page":"165","article-title":"Two cases of disseminated polyposis of colon","volume":"33","author":"Cripps WH","year":"1882","journal-title":"Trans Pol Soc"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.12.959"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250309"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/328614a0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3479843"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280563"},{"key":"e_1_2_7_12_1","first-page":"95","article-title":"The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management","volume":"8","author":"Leoz ML","year":"2015","journal-title":"Appl Clin Genet"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.3046"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(00)01828-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579760"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430621"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.6.867"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20698"},{"key":"e_1_2_7_19_1","first-page":"8","article-title":"Detecting mutations in the APC gene in familial adenomatous polyposis (FAP)","author":"Hegde MR","year":"2006","journal-title":"Curr Protoc Hum Genet"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-22"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292702"},{"key":"e_1_2_7_22_1","first-page":"421","article-title":"The genetics of familial adenomatous polyposis (FAP) and MutYH\u2010associated polyposis (MAP)","volume":"74","author":"Claes K","year":"2011","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199906000-00003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80005-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390180093030"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.20.1626"},{"key":"e_1_2_7_27_1","first-page":"668","article-title":"Hepatoblastoma in a patient with familial polyposis coli","volume":"105","author":"LeSher AR","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170518"},{"key":"e_1_2_7_29_1","first-page":"123","article-title":"Hepatoblastoma with familial polyposis coli: another case and corrected pedigree","volume":"108","author":"Toyama WM","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901201)66:11<2429::AID-CNCR2820661131>3.0.CO;2-W"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950180204"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02048117"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199208000-00018"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.3.8394642"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290211"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80297-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940415)73:8<2065::AID-CNCR2820730809>3.0.CO;2-O"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179614"},{"key":"e_1_2_7_39_1","first-page":"5007","article-title":"Biallelic inactivation of the APC gene in hepatoblastoma","volume":"55","author":"Kurahashi H","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_7_40_1","first-page":"3320","article-title":"Somatic mutations of the APC gene in sporadic hepatoblastomas","volume":"56","author":"Oda H","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.3.417"},{"key":"e_1_2_7_42_1","first-page":"14","article-title":"Molecular analysis of the APC gene in 205 families: extended genotype\u2010phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition","volume":"36","author":"Wallis YL","year":"1999","journal-title":"J Med Genet"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90164-1"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203356"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012330626600"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.3.230"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00618-X"},{"key":"e_1_2_7_48_1","first-page":"121","article-title":"Nuclear accumulation of beta\u2010catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient","volume":"11","author":"Inukai T","year":"2004","journal-title":"Oncol Rep"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20556"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922809332681"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160909500629"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181e1a224"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v56i2.3112"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.6138"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-012-9538-2"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825f377f"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318232d4db"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828aeb18"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-014-9718-3"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.09.033"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26892"},{"key":"e_1_2_7_62_1","unstructured":"OlschwangS FabreA GrandvalP.The universal mutation database.2015.http:\/\/www.umd.be\/APC\/. Update on January 4th."},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020052"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.6013"},{"key":"e_1_2_7_65_1","article-title":"Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups","author":"Sumazin P","year":"2016","journal-title":"Hepatology"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.07.012"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800977"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-005-0028-5"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.07.022"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-04-0885"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22135"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.02.009"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.08.003"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.01.004"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22059"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.07.011"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.4161\/tisb.24965"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4452"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.050070"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.05.526"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28763"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.2741\/e393"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318174e808"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<399::AID-GCC14>3.0.CO;2-X"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00433-4"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1280"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.435"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-016-9905-5"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-016-0030-2"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9090-6"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.4065\/75.1.57"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.05.038"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24655"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70008-3"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T07:08:52Z","timestamp":1695452932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,2]]},"references-count":93,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/pbc.27103"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27103","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,2]]},"assertion":[{"value":"2017-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27103"}}