{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:42:45Z","timestamp":1765294965037,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ALSAC (American Lebanese Syrian Associated Charities)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Primary pancreatic carcinoma and pancreatic metastases are rare in the pediatric population. Pancreatoblastoma is the most common pancreatic malignant tumor in young children and solid\u2010pseudopapillary tumor in teenagers. Pancreatic adenocarcinoma is extremely rare under the age of 40 and is usually associated with underlying genetic abnormalities. Secondary malignancies of the pancreas occur more frequently than primary pancreatic malignancies in children and are most commonly seen with non\u2010Hodgkin lymphomas (NHL) and mesenchymal sarcomas. The purpose of this study was to characterize the metabolism of primary and secondary tumors of the pancreas in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A retrospective analysis of all primary and secondary pancreatic malignancies imaged with 18F\u2010fluorodeoxyglucose (FDG)\u2013positron emission tomography (PET) computed tomography (CT) was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients with primary pancreatic cancers were identified, one each with pancreatoblastoma, solid\u2010pseudopapillary tumor, and adenocarcinoma. Each tumor showed elevated uptake of FDG. Metastatic disease in the pancreas was identified in 12 patients\u2014five NHL (including three Burkitt lymphomas), six sarcomas (three osteosarcomas, two rhabdomyosarcomas, and one Ewing sarcoma family tumor), and one malignant rhabdoid tumor. Elevated but variable uptake of FDG was found in each of the tumors of patients with metastatic disease within the pancreas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both primary malignancies and metastatic disease within the pancreas, though very rare in children, adolescents, and young adults, are metabolically active and can be functionally characterized using FDG\u2013PET CT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27115","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T12:32:27Z","timestamp":1526041947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["FDG\u2013PET CT in the evaluation of primary and secondary pancreatic malignancies"],"prefix":"10.1002","volume":"65","author":[{"given":"Casey E.","family":"Bohl","sequence":"first","affiliation":[{"name":"Department of Radiology Methodist University Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara M.","family":"Federico","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giles W.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-2649","authenticated-orcid":false,"given":"Armita","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-7914","authenticated-orcid":false,"given":"Barry L.","family":"Shulkin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging St. Jude Children's Research Hospital  Memphis Tennessee"},{"name":"Department of Radiology University of Tennessee Health Science Center  Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"467","article-title":"Management of pancreatic neuroendocrine tumors","volume":"56","author":"Dabizzi E","year":"2010","journal-title":"Minerva Gastroenterol Dietol"},{"key":"e_1_2_9_3_1","first-page":"239","article-title":"Imaging features of pancreatic neoplasms","volume":"84","author":"Ros PR","year":"2001","journal-title":"JBR\u2010BTR"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.314105731"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31824e3839"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.357"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0033-8389(22)02127-3","article-title":"Rare pancreatic malignancies","volume":"27","author":"Friedman AC","year":"1989","journal-title":"Radiol Clin North Am"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2007.12.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.71.851.10434919"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198509000-00008"},{"key":"e_1_2_9_11_1","first-page":"683","article-title":"EUS diagnosis of a primary pancreatic metastasis of alveolar rhabdomyosarcoma","volume":"10","author":"Vanwoerkom RC","year":"2009","journal-title":"JOP"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-010-1572-3"},{"key":"e_1_2_9_13_1","first-page":"438","article-title":"A case of primary vertebral osteosarcoma metastasizing to pancreas","volume":"10","author":"Avcu S","year":"2009","journal-title":"JOP"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.18.5.9747614"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388718"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1476"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.264065012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.195.2.7724751"},{"key":"e_1_2_9_19_1","first-page":"454","article-title":"Diagnosis and treatment of solid\u2010pseudopapillary tumor of the pancreas","volume":"5","author":"Zhang H","year":"2006","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"e_1_2_9_20_1","first-page":"1S","article-title":"A tabulated summary of the FDG PET literature","volume":"42","author":"Gambhir SS","year":"2001","journal-title":"J Nucl Med"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-5659-6_15"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/16642775"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2002.36657"},{"key":"e_1_2_9_24_1","first-page":"4573","article-title":"Extrarenal malignant rhabdoid tumour of the heel\u2014a case report","volume":"25","author":"Mazzocchi M","year":"2005","journal-title":"Anticancer Res"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T08:44:45Z","timestamp":1694940285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,11]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/pbc.27115"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27115","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2018,5,11]]},"assertion":[{"value":"2017-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27115"}}