{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:12:35Z","timestamp":1778551955352,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502652"],"award-info":[{"award-number":["81502652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to present long\u2010term results of mandibular growth in pediatric parotid gland carcinoma survivors treated with interstitial brachytherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Twenty\u2010five survivors of pediatric parotid gland carcinoma treated with iodine\u2010125 seed interstitial brachytherapy were included for quantitative analysis, including three dimensional (3D) cephalometry and measurement of mandibular volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3D cephalometry showed that the median fore\u2010and\u2010aft increments of the lengths of the condyle, the ramus, and the body of the mandible were 1.23, 0.19, and 1.66\u00a0mm for the affected side, respectively, and were 1.37, 1.95, and 3.42\u00a0mm for the unaffected side, respectively. The difference in increments of the ramus was statistically significant between the affected side and the unaffected side (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Moreover, mandibular volume measurements showed that the median fore\u2010and\u2010aft increments of the volumes of the condyle, the ramus, and the body of the mandible were 290.62, 220.14, and 1706.40 mm<jats:sup>3<\/jats:sup> for the affected side, respectively, and were 269.15, 370.40, and 1469.86 mm<jats:sup>3<\/jats:sup> for the unaffected side, respectively. The difference in increments was statistically significant between the affected side and the unaffected side for the ramus (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and the body (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mandibular growth was affected by interstitial brachytherapy, especially for the ramus, in pediatric parotid gland carcinoma survivors treated with interstitial brachytherapy. Nevertheless, the impact was mild in these survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27223","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T15:30:32Z","timestamp":1527175832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mandibular growth in survivors of pediatric parotid gland carcinoma treated with interstitial brachytherapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Wen\u2010Jie","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology  Beijing 100081 P. R. 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