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Although the 5\u2010year overall survival rate has increased over the past few decades, high\u2010risk patients still have a poor prognosis due to a lack of biomonitoring therapy. This study was performed to investigate the role of Galectin\u20101 in neuroblastoma biomonitoring therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A tissue microarray containing 37 neuroblastoma tissue samples was used to evaluate the correlation between Galectin\u20101 expression and clinical features. Blood samples were examined to better understand whether serum Galectin\u20101 (sGalectin\u20101) could be used for biomonitoring therapy. Kaplan\u2013Meier analysis and ROC analysis was conducted to distinguish the outcome associated with high or low expression of Galectin\u20101 in patients with neuroblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased Galectin\u20101 expression was found in neuroblastoma and it was further demonstrated that elevated tissue Galectin\u20101 expression was related to INSS stage, histology, bone marrow metastasis, and poor survival. sGalectin\u20101 levels were higher in newly diagnosed patients with neuroblastoma than healthy subjects. Patients with elevated sGalectin\u20101 through treatment cycles correlated with the poor chemo\u2010responses and tended to have worse outcomes, such as metastasis or stable tumor size, whereas gradually decreasing sGalectin\u20101 levels correlated with no observed progression in clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tissue and serum Galectin\u20101 levels were associated with adverse clinical features in patients with neuroblastoma, and sGalectin\u20101 could be a potential biomarker for monitoring therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27229","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T15:16:08Z","timestamp":1527174968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Both serum and tissue Galectin\u20101 levels are associated with adverse clinical features in neuroblastoma"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-0184","authenticated-orcid":false,"given":"Kai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Xinhua Hospital School of Medicine Shanghai Jiaotong University  Shanghai China"},{"name":"Division of Pediatric Oncology Shanghai Institute of Pediatric Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxia","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Xinhua Hospital School of Medicine Shanghai Jiaotong University  Shanghai China"},{"name":"Division of Pediatric Oncology Shanghai Institute of Pediatric Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Xinhua Hospital School of Medicine Shanghai Jiaotong University  Shanghai China"},{"name":"Division of Pediatric Oncology Shanghai Institute of Pediatric Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Xinhua Hospital School of Medicine Shanghai Jiaotong University  Shanghai China"},{"name":"Division of Pediatric Oncology Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Department of Pediatric Surgery Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8845-1820","authenticated-orcid":false,"given":"Yeming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Xinhua Hospital School of Medicine Shanghai Jiaotong University  Shanghai China"},{"name":"Division of Pediatric Oncology Shanghai Institute of Pediatric Research  Shanghai China"},{"name":"Department of Pediatric Surgery Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804577"},{"key":"e_1_2_9_3_1","volume-title":"Health Professional Version: PDQ Cancer Information Summaries","author":"Board PDQPTE. 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