{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:30:26Z","timestamp":1781854226366,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advances in radiation treatment (RT), specifically volumetric planning with detailed dose and volumetric data for specific brain structures, have provided new opportunities to study neurobehavioral outcomes of RT in children treated for brain tumor. The present study examined the relationship between biophysical and physical dose metrics and neurocognitive ability, namely learning and memory, 2 years post\u2010RT in pediatric brain tumor patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The sample consisted of 26 pediatric patients with brain tumor, 14 of whom completed neuropsychological evaluations on average 24 months post\u2010RT. Prescribed dose and dose\u2013volume metrics for specific brain regions were calculated including physical metrics (i.e., mean dose and maximum dose) and biophysical metrics (i.e., integral biological effective dose and generalized equivalent uniform dose). We examined the associations between dose\u2013volume metrics (whole brain, right and left hippocampus), and performance on measures of learning and memory (Children's Memory Scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biophysical dose metrics were highly correlated with the physical metric of mean dose but not with prescribed dose. Biophysical metrics and mean dose, but not prescribed dose, correlated with measures of learning and memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary findings call into question the value of prescribed dose for characterizing treatment intensity; they also suggest that biophysical dose has only a limited advantage compared to physical dose when calculated for specific regions of the brain. We discuss the implications of the findings for evaluating and understanding the relation between RT and neurocognitive functioning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27245","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T12:51:32Z","timestamp":1527857492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dose\u2013volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-181X","authenticated-orcid":false,"given":"Kimberly P.","family":"Raghubar","sequence":"first","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine and Texas Children's Hospital  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lamba","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Cincinnati College of Medicine  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cincinnati College of Medicine and the Imaging Research Center, Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith Owen","family":"Yeates","sequence":"additional","affiliation":[{"name":"Department of Psychology Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Mark","family":"Mahone","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Department of Psychiatry Kennedy Krieger Institute and Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Limke","sequence":"additional","affiliation":[{"name":"Helen DeVos Children's Hospital  Grand Rapids Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grosshans","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"Beckwith","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cincinnati College of Medicine and the Imaging Research Center, Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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