{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:02:29Z","timestamp":1792245749189,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive mold infections (IMIs) are a leading cause of mortality among immunocompromised patients. Isavuconazole is a new drug that shows promise in the adult population for the treatment of IMIs. No data regarding the use of isavuconazole in pediatric patients have been published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a diagnosis of IMI from our pediatric hemato\u2010oncology division, treated with isavuconazole between 2010 and 2016, were identified using the hospital's computerized database. Data including demographics, clinical course, and outcome were collected. Pharmacokinetic samples were obtained from two younger patients to guide dosing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, three patients (4.5, 5, and 19 years of age) with invasive mucormycosis who were treated with isavuconazole were identified. All patients were treated with isavuconazole as a second line therapy and experienced improvement following the initiation of this treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on our limited clinical experience, isavuconazole may be a safe and effective treatment option for children and adolescents afflicted by IMI. Prospective clinical trials should be performed in order to evaluate the pharmakokinetics and safety of isavuconazole in the pediatric population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27281","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T11:33:09Z","timestamp":1529667189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Successful treatment of invasive mucormycosis with isavuconazole in pediatric patients"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-8409","authenticated-orcid":false,"given":"Assaf A.","family":"Barg","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Oncology &amp; BMT The Edmond and Lily Safra Children's Hospital Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Malkiel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology &amp; BMT The Edmond and Lily Safra Children's Hospital Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Bartuv","sequence":"additional","affiliation":[{"name":"Pharmacy Services Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gahl","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic imaging Sheba Medical Center  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Toren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology &amp; BMT The Edmond and Lily Safra Children's Hospital Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Keller","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"The Department of Health Management Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2008.01056.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu074"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir866"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2015.1092058"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2005-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-012-0272-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-316430"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12466"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.04.023"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00071-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02025.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-77"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31825d649a"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1542\/peds.113.S3.1128","article-title":"Changing requirements for evaluation of pharmacologic agents","volume":"113","author":"Chesney RW","year":"2004","journal-title":"Pediatrics"},{"key":"e_1_2_6_18_1","first-page":"163","article-title":"Profile of isavuconazole and its potential in the treatment of severe invasive fungal infections","volume":"6","author":"Falci DR","year":"2013","journal-title":"Infect Drug Resist"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2016.03.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0552-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S90335"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0227-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30541-2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.152900"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12371"}],"container-title":["Pediatric Blood &amp; 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