{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:23Z","timestamp":1786978283337,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T00:00:00Z","timestamp":1529625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["2535363301 2 K12 CA090433\u201016 POPLACK"],"award-info":[{"award-number":["2535363301 2 K12 CA090433\u201016 POPLACK"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>\n \n Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that has been associated with\n EWSR1\u2010CREB1<\/jats:italic>\n gene fusion. Outcome in patients with unresectable distant metastases is generally fatal. Interleukin\u20106 (IL\u20106) secretion has been described in tumors with\n EWSR1\u2010CREB1<\/jats:italic>\n fusion, and may promote tumor growth due to autocrine stimulation. Tocilizumab is an IL\u20106 receptor antibody that has potential benefit as a targeted therapy in refractory neoplasms with IL\u20106 secretion. We describe a child with metastatic AFH with\n EWSR1\u2010CREB1<\/jats:italic>\n fusion and elevated IL\u20106 whose disease progressed during treatment with traditional chemotherapeutic agents, but improved after targeted therapy with tocilizumab.\n <\/jats:p>","DOI":"10.1002\/pbc.27291","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T07:36:51Z","timestamp":1529653011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Therapeutic response of metastatic angiomatoid fibrous histiocytoma carrying\n EWSR1\u2010CREB1<\/i>\n fusion to the interleukin\u20106 receptor antibody tocilizumab"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-953X","authenticated-orcid":false,"given":"Samara L.","family":"Potter","sequence":"first","affiliation":[{"name":"Department of Pediatrics Texas Children's Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma M.","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Texas Children's Hospital and Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle K.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Texas Children's Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindi","family":"Naik\u2010Mathuria","sequence":"additional","affiliation":[{"name":"Department of Surgery Texas Children's Hospital and Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Venkatramani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Texas Children's Cancer Center Baylor College of Medicine Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2147::AID-CNCR2820440627>3.0.CO;2-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90065-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199012000-00004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000313"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20491"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000390"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket452"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2291"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26376"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825485c5"}],"container-title":["Pediatric Blood & Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T04:45:42Z","timestamp":1694925942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,22]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/pbc.27291"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27291","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,22]]},"assertion":[{"value":"2018-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27291"}}