{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:03:46Z","timestamp":1753869826141,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1012250"],"award-info":[{"award-number":["1012250"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While several studies have examined the treatment of adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL), studies of acute myeloid leukemia (AML) are rare. Using national data for Australia, we describe (i) the number and type of treatment centers caring for AYAs, (ii) induction\/first\u2010line treatments, and (iii) survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>National population\u2010based study assessing treatment of 15\u2010 to 24\u2010year\u2010olds diagnosed with ALL or AML between 2007 and 2012. Treatment details were abstracted from hospital medical records. Treatment centers were classified as pediatric or adult (adult AYA\u2010focused or other adult; and by AYA volume [high\/low]). Cox proportional hazard regression analyses examined associations between treatment and overall, event\u2010free, and relapse\u2010free survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven hospitals delivered induction therapy to 351 patients (181 ALL and 170 AML), with 74 (21%) treated at pediatric centers; 70% of hospitals treated less than two AYA leukemia patients per year. Regardless of treatment center, 82% of ALL patients were on pediatric protocols. For AML, pediatric protocols were not used in adult centers, with adult centers using a non\u2010COG 7+3\u2010type induction protocol (51%, where COG is Cooperative Oncology Group) or an ICE\u2010type protocol (39%, where ICE is idarubicin, cytarabine, etoposide). Exploratory analyses suggested that for both ALL and AML, AYAs selected for adult protocols have worse overall, event\u2010free, and relapse\u2010free survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pediatric protocols were commonly used for ALL patients regardless of where they are treated, indicating rapid assimilation of recent evidence by Australian hematologists. For AML, pediatric protocols were only used at pediatric centers. Further investigation is warranted to determine the optimal treatment approach for AYA AML patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27349","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T11:36:27Z","timestamp":1532432187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical management of Australian adolescents and young adults with acute lymphoblastic and myeloid leukemias: A national population\u2010based study"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-8484","authenticated-orcid":false,"given":"V. M.","family":"White","sequence":"first","affiliation":[{"name":"Centre for Behavioural Research in Cancer Cancer Council Victoria  Melbourne Victoria Australia"},{"name":"School of Psychology Deakin University  Burwood Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-3563","authenticated-orcid":false,"given":"G.","family":"Skaczkowski","sequence":"additional","affiliation":[{"name":"Centre for Behavioural Research in Cancer Cancer Council Victoria  Melbourne Victoria Australia"},{"name":"School of Psychology and Public Health La Trobe University  Bundoora Victoria Australia"},{"name":"Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pinkerton","sequence":"additional","affiliation":[{"name":"Children's Health Queensland Hospital and Health Service  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Coory","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre The Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital South Australia  Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bibby","sequence":"additional","affiliation":[{"name":"Centre for Behavioural Research in Cancer Cancer Council Victoria  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Children's Health Queensland Hospital and Health Service  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M.","family":"Orme","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-1365","authenticated-orcid":false,"given":"R.","family":"Conyers","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Princess Margaret Hospital for Children  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Harrup","sequence":"additional","affiliation":[{"name":"Royal Hobart Hospital  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Walker","sequence":"additional","affiliation":[{"name":"Children's Health Queensland Hospital and Health Service  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Anazodo","sequence":"additional","affiliation":[{"name":"Kids Cancer Centre Sydney Children's Hospital  Randwick New South Wales Australia"},{"name":"Nelune Comprehensive Cancer Centre Prince of Wales Hospital  Randwick New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1001\/jamapediatrics.2015.4689"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1016\/j.ejca.2015.08.010"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1002\/cncr.29869"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.5694\/j.1326-5377.2010.tb03871.x"},{"volume-title":"Cancer in adolescents and young adults in Australia","year":"2011","author":"Australian Institute of Health and Welfare","key":"e_1_2_7_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1089\/jayao.2014.0041"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1002\/pon.4625"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1002\/cncr.30322"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1182\/blood-2014-11-551481"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1182\/asheducation-2006.1.128"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1002\/ajh.23149"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1182\/blood-2008-01-130237"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1001\/jamaoncol.2017.5305"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1002\/pbc.20749"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1002\/cncr.28344"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.4084\/mjhid.2014.032"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1093\/annonc\/mdw171"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1016\/j.beha.2014.04.003"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1182\/blood-2005-10-4006"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1038\/bcj.2015.25"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_1","DOI":"10.1007\/s11899-014-0205-6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_1","DOI":"10.1089\/jayao.2012.0032"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_1","DOI":"10.1002\/pbc.26326"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_1","DOI":"10.1158\/1055-9965.EPI-16-0722"},{"doi-asserted-by":"publisher","key":"e_1_2_7_26_1","DOI":"10.1093\/annonc\/mds518"},{"doi-asserted-by":"publisher","key":"e_1_2_7_27_1","DOI":"10.1159\/000360200"},{"doi-asserted-by":"publisher","key":"e_1_2_7_28_1","DOI":"10.1093\/jnci\/dju300"},{"doi-asserted-by":"publisher","key":"e_1_2_7_29_1","DOI":"10.1016\/j.ejca.2015.06.112"},{"doi-asserted-by":"publisher","key":"e_1_2_7_30_1","DOI":"10.1002\/ijc.30186"},{"doi-asserted-by":"publisher","key":"e_1_2_7_31_1","DOI":"10.1016\/j.clml.2016.09.011"},{"doi-asserted-by":"publisher","key":"e_1_2_7_32_1","DOI":"10.1200\/JCO.2003.02.053"},{"doi-asserted-by":"publisher","key":"e_1_2_7_33_1","DOI":"10.1038\/sj.leu.2403538"},{"doi-asserted-by":"publisher","key":"e_1_2_7_34_1","DOI":"10.1002\/cncr.23220"},{"doi-asserted-by":"publisher","key":"e_1_2_7_35_1","DOI":"10.1002\/cncr.27659"}],"container-title":["Pediatric Blood &amp; 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