{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:03:53Z","timestamp":1753869833088,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present five patients with coexistent von Willebrand disease (VWD) and Ehlers\u2010Danlos syndrome and 21 with VWD and joint hypermobility. Females outnumbered males ten to three, Beighton scores were documented in 58% (15 of 26 patients), and several patients experienced moderately severe bleeding. We believe coexistent hypermobility disorder with VWD potentially affects bleeding severity and want to raise awareness among hematologists. Evaluation by geneticists is recommended because of the varying complexities observed across the disease spectrum, and the availability of new genetic tests should lead to more accurate diagnoses for the various hypermobility disorders.<\/jats:p>","DOI":"10.1002\/pbc.27370","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:38:19Z","timestamp":1533645499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical features of children, adolescents, and adults with coexisting hypermobility syndromes and von Willebrand disease"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-3035","authenticated-orcid":false,"given":"Sarah A.","family":"Hall","sequence":"first","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-9239","authenticated-orcid":false,"given":"Emily Riehm","family":"Meier","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweta","family":"Gupta","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Nakar","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeli","family":"Rampersad","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal","family":"Bakeer","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-3898","authenticated-orcid":false,"given":"Brandon","family":"Hardesty","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjusha","family":"Kumar","sequence":"additional","affiliation":[{"name":"Indiana Hemophilia &amp; Thrombosis Center  Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"volume-title":"The Diagnosis, Evaluation, and Management of Von Willebrand Disease","year":"2007","author":"The National Heart, Lung, and Blood Institute","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31539"},{"key":"e_1_2_7_5_1","first-page":"573","article-title":"Colonic perforation: a rare complication in a patient with Ehlers\u2010Danlos syndrome and von Willebrand's disease","volume":"158","author":"McAleese P","year":"1992","journal-title":"Eur J Surg"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12931"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb06063.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05220.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31538"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T16:13:00Z","timestamp":1694794380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/pbc.27370"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27370","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"assertion":[{"value":"2018-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1800-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27370"}}