{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:03:49Z","timestamp":1753869829291,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010risk neuroblastoma (HR NBL) treatment requires intensive induction chemotherapy. The profoundly emetogenic agents used can compromise nutritional status. Our institution introduced a new antiemetic guideline in 2010 incorporating regular dexamethasone, in addition to ondansetron, for all highly emetogenic protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A retrospective comparative review of pediatric patients diagnosed with HR NBL who received rapid COJEC induction chemotherapy as per HR\u2010SIOPEN NBL trial. Prophylactic antiemetics were prescribed regardless of chemotherapy emetogenicity in group A (2004\u20132010) but for defined time periods considering chemotherapy emetogenicity in group B (2010\u20132017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three children were eligible for inclusion (median age, 31 months; range, 1\u201388 months). Group A had more episodes of emesis than group B (189 vs. 116, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). There was a significant difference in weight\u2010for\u2010age Z score change between the groups by induction end (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0027). Four children (13%) in group A lost &gt;10% body weight versus none in group B. Nutrition support (NS) was utilized by 29 children (94%) in group A and 22 children (69%) in group B. Group A had a median of 3 (range, 1\u20137) admissions for febrile neutropenia (FN) versus a median of 1.5 (range, 0\u20134) for group B (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) during induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The review of our guidelines led to reduced emesis frequency for group B. They also required less NS, followed expected growth trajectories more closely and had fewer FN admissions. We propose that this may have occurred due to better emesis control resulting in improved nutritional status and associated enhanced immune function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.27386","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:06:40Z","timestamp":1537358800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Revised antiemetics guidelines and the impact on nutritional status during induction chemotherapy in children with high\u2010risk neuroblastoma"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-8392","authenticated-orcid":false,"given":"Catherine","family":"Carroll","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frieda","family":"Clinton","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisling","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aine","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Capra","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Pears","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cormac","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Our Lady's Children's Hospital Crumlin  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","author":"Phillips RD","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2010.04.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000141"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318163a2d4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830815)52:4<587::AID-CNCR2820520402>3.0.CO;2-T"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11833"},{"issue":"2","key":"e_1_2_8_8_1","author":"Ward EJ","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2350-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.12.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.05.014"},{"key":"e_1_2_8_12_1","first-page":"56","volume-title":"Dietary reference values for energy","author":"Scientific Advisory Committee on Nutrition (Energy Requirements Working Group)","year":"2011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.3524"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24508"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare4030036"},{"key":"e_1_2_8_16_1","first-page":"1","article-title":"Nutritional status and nutritional management in children with cancer","volume":"0","author":"Gaynor EPT","year":"2015","journal-title":"Arch Dis Child"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533616671861"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1747-0080.12336"}],"container-title":["Pediatric Blood &amp; 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