{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:43:03Z","timestamp":1792568583506,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Istituto Pasteur Italia Fondazione Cenci Bolognetti"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV)\u2010related lymphoproliferative disorders are relatively common in Iraqi children. Burkitt lymphoma (BL) accounted for 40% of lymphoma cases. The mean age of 125 BL cases was 5.9 \u00b1 3.1 years, and the male\u2010to\u2010female ratio was 3.6:1. Clinical presentation was abdominal in 66% and head and neck in 34%. Bone marrow involvement was higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in children with head and neck disease. Tumor cells had <jats:italic>MYC<\/jats:italic> translocation (96%) and were CD20<jats:sup>+<\/jats:sup>\/CD10<jats:sup>+<\/jats:sup>\/MYC<jats:sup>+<\/jats:sup>\/BCL2<jats:sup>\u2212<\/jats:sup>. MUM1\/IRF4 staining was expressed by a fraction of tumor cells in 19 of 125 cases (15%) and was more frequent (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.007) in head and neck disease (12\/42; 29%). EBV\u2010encoded RNA was positive in 100 of 125 (80%) BL cases.<\/jats:p>","DOI":"10.1002\/pbc.27399","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T05:55:10Z","timestamp":1536731710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Burkitt lymphoma in Iraqi children: A distinctive form of sporadic disease with high incidence of EBV<sup>+<\/sup> cases and more frequent expression of MUM1\/IRF4 protein in cases with head and neck presentation"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-7860","authenticated-orcid":false,"given":"Stefania","family":"Uccini","sequence":"first","affiliation":[{"name":"Istituto Pasteur Italia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazin F.","family":"Al\u2010Jadiry","sequence":"additional","affiliation":[{"name":"Children's Welfare Teaching Hospital Baghdad College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cippitelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Pathology Unit Sapienza University Sant'Andrea Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Talerico","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Pathology Unit Sapienza University Sant'Andrea Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Scarpino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Pathology Unit Sapienza University Sant'Andrea Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir F.","family":"Al\u2010Darraji","sequence":"additional","affiliation":[{"name":"Children's Welfare Teaching Hospital Baghdad College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa A. F.","family":"Al\u2010Badri","sequence":"additional","affiliation":[{"name":"Children's Welfare Teaching Hospital Baghdad College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel R.","family":"Alsaadawi","sequence":"additional","affiliation":[{"name":"Department of Pathology Baghdad Medical City Complex  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma A.","family":"Al\u2010Hadad","sequence":"additional","affiliation":[{"name":"Children's Welfare Teaching Hospital Baghdad College of Medicine  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ruco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Pathology Unit Sapienza University Sant'Andrea Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1967.77"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.09013.x"},{"key":"e_1_2_8_5_1","first-page":"447","volume-title":"Hematopathology","author":"Gascoyne RD","year":"2017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7837"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24654"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.01.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880373"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/7CEAWV0DNLLUWQTF"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.07.021"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000804"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210108"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453308X315942"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009065832"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02986618"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60278-X"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2009.10.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/274756a0"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.27399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.27399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T16:12:25Z","timestamp":1694794345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,11]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/pbc.27399"],"URL":"https:\/\/doi.org\/10.1002\/pbc.27399","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,11]]},"assertion":[{"value":"2018-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e27399"}}